Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Polygalacturonic acid
Price: ￥5358.0/500g ￥418.0/25g ￥1048.0/100g
Purity: 98.0%
Stocking Period: Inquiry
Contact: Liu jia

25990-10-7

25990-10-7 structure

Name: Polygalacturonic acid
Chemical Name: D-Galacturonic acid
CAS Number: 25990-10-7
Molecular Formula: C₆H₁₀O₇
Molecular Weight: 194.139
Catalog: Research Areas Infection
Create Date: 2018-05-16 10:05:15
Modify Date: 2024-01-01 23:08:23
Polygalacturonic acid (Galacturonic acid polymer) is transparent colloid, is a major component of the cell wall. Polygalacturonic acid can be used to prepare silver nanoparticles (AgNPs), as an antioxidant and anti-inflammatory that protect cells from destructive effect of elevated ROS and accelerate wound healing. Polygalacturonic acid nanoparticles also displays anti-bacterial activity[1][2].

Name	D-Galacturonic acid
Synonyms	DL-Galacturonic acid α-D-Galacturonic acid MFCD00131972 D-Galacturonic acid (9CI) D-Galacturonic acid δ-Galacturonic acid

Description	Polygalacturonic acid (Galacturonic acid polymer) is transparent colloid, is a major component of the cell wall. Polygalacturonic acid can be used to prepare silver nanoparticles (AgNPs), as an antioxidant and anti-inflammatory that protect cells from destructive effect of elevated ROS and accelerate wound healing. Polygalacturonic acid nanoparticles also displays anti-bacterial activity[1][2].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology
In Vitro	Polygalacturonic acid can be used to format a durable hydrogel, to prolong the effect of drugs. Polygalacturonic acid hydrogel/hyaluronate, conjugated Ibuprofen (HY-78131) for example, prevents epidural fibrosis, the severe scar tissue adhesion of laminectomized male adult rats, and increases the efficiency of local inflammation control and reduces the side-effect of Ibuprofen[1]. Polygalacturonic acid hydrogel/hyaluronate (PGA-HA) (2%, 200 μL; 24 h) shows low cytotoxicity on L929 fibroblasts[1]. Polygalacturonic acid (PGA) preparing (Ag-PGA/HA)-PVA nanoparticles, shows anti-bacterial activity against gram-positive bacterial strains; Bacillus Subtilis and Staphylococcus Aureus, as well as gram-negative bacterial strain; Escherichia Coli[2].
In Vivo	Polygalacturonic acid (external application; 14 d) enhances a quick healing of wound infection in albino rats[2]. Animal Model: Full thickness wound model in albino rats (60-day-old, 180 g)[2] Dosage: Ag-Polygalacturonic acid/hyaluronic acid nanoparticles Administration: Applied on dorsal muscle fascia; cleaned the wound daily with alcohol; for 14 days Result: Resulted no sign of abscess formation or hypertrophic scars both in the early phase; 5th day or in the final phase; 14th day, respectively. Showed significant wound healing from day 8 while treated with (Ag-PGA/HA)-PVA nanofiber and blank (PGA/HA)-PVA nanofiber and induced epithelization on day 14.
References	[1]. Lin CY, et al. Ibuprofen-conjugated hyaluronate/polygalacturonic acid hydrogel for the prevention of epidural fibrosis. J Biomater Appl. 2016 May;30(10):1589-600. [2]. El-Aassar MR, et al. Wound healing of nanofiber comprising Polygalacturonic/Hyaluronic acid embedded silver nanoparticles: In-vitro and in-vivo studies. Carbohydr Polym. 2020 Jun 15;238:116175.

Density	1.7±0.1 g/cm3
Boiling Point	553.4±50.0 °C at 760 mmHg
Molecular Formula	C₆H₁₀O₇
Molecular Weight	194.139
Flash Point	302.6±26.6 °C
Exact Mass	194.042648
LogP	-1.49
Vapour Pressure	0.0±3.4 mmHg at 25°C
Index of Refraction	1.592

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xi
RIDADR	NONH for all modes of transport

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