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  • DC Chemicals Limited
  • China
  • Product Name: SPDB
  • Price: $250.0/100mg $500.0/250mg $1000.0/1g
  • Purity: 98.0%
  • Stocking Period: 3 Day
  • Contact: Tony Cao

115088-06-7

115088-06-7 structure
115088-06-7 structure
  • Name: N-Succinimidyl 4-(2-pyridyldithio)butanoate
  • Chemical Name: 1-{[4-(2-Pyridinyldisulfanyl)butanoyl]oxy}-2,5-pyrrolidinedione
  • CAS Number: 115088-06-7
  • Molecular Formula: C13H14N2O4S2
  • Molecular Weight: 326.391
  • Catalog: Research Areas Others
  • Create Date: 2018-02-04 02:01:16
  • Modify Date: 2024-01-04 17:55:12
  • SPDB is a small fragment that can linked DM4 conjugates. Conjugated to antibodies utilizing disulfide linkers: anti-EGFR-SPDB-DM4 has been widely used.

Name 1-{[4-(2-Pyridinyldisulfanyl)butanoyl]oxy}-2,5-pyrrolidinedione
Synonyms 1-{[4-(2-Pyridinyldisulfanyl)butanoyl]oxy}-2,5-pyrrolidinedione
2,5-Pyrrolidinedione, 1-[1-oxo-4-(2-pyridinyldithio)butoxy]-
SPDB
Description SPDB is a small fragment that can linked DM4 conjugates. Conjugated to antibodies utilizing disulfide linkers: anti-EGFR-SPDB-DM4 has been widely used.
Related Catalog
References

[1]. Widdison WC et al. Development of Anilino-Maytansinoid ADCs that Efficiently Release Cytotoxic Metabolitesin Cancer Cells andInduce High Levels of Bystander Killing. Bioconjug Chem, 2015 Nov 18, 26(11):2261-78.

Density 1.4±0.1 g/cm3
Boiling Point 480.1±55.0 °C at 760 mmHg
Molecular Formula C13H14N2O4S2
Molecular Weight 326.391
Flash Point 244.2±31.5 °C
Exact Mass 326.039490
LogP 1.21
Vapour Pressure 0.0±1.2 mmHg at 25°C
Index of Refraction 1.637
Storage condition 2-8℃