1439901-97-9

1439901-97-9 structure

Name: ONO4059 hydrochloride
Chemical Name: ONO-4059
CAS Number: 1439901-97-9
Molecular Formula: C₂₅H₂₃ClN₆O₃
Molecular Weight: 490.941
Catalog: Signaling Pathways Protein Tyrosine Kinase/RTK Btk
Create Date: 2018-02-16 22:15:36
Modify Date: 2024-01-06 11:52:45
Tirabrutinib (ONO-4059) hydrochloride is a selective and novel inhibitor of BTK with IC50 2.2 nm, Tirabrutinib binds to BTK within B cells, thereby preventing B-cell receptor signaling and impeding B-cell development.

Name	ONO-4059
Synonyms	8H-Purin-8-one, 6-amino-7,9-dihydro-9-[(3R)-1-(1-oxo-2-butyn-1-yl)-3-pyrrolidinyl]-7-(4-phenoxyphenyl)-, hydrochloride (1:1) 6-Amino-9-[(3R)-1-(2-butynoyl)-3-pyrrolidinyl]-7-(4-phenoxyphenyl)-7,9-dihydro-8H-purin-8-one hydrochloride (1:1) ONO4059 hydrochloride ONO-4059(HCl salt) ONO-4059 (hydrochloride)

Description	Tirabrutinib (ONO-4059) hydrochloride is a selective and novel inhibitor of BTK with IC50 2.2 nm, Tirabrutinib binds to BTK within B cells, thereby preventing B-cell receptor signaling and impeding B-cell development.
Related Catalog	Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Btk Research Areas >> Cancer
Target	IC50: 2.2 nM (BTK)[1].
References	[1]. Akintunde Akinleye et al. Ibrutinib and novel BTK inhibitors in clinical development. J Hematol Oncol, 2013, 6: 59. [2]. Harriet S et al. A phase 1 clinical trial of the selective BTK inhibitor ONO/GS-4059 in relapsed and refractory mature B-cell malignancies. Blood 2016, 127:411-419.

Hazard Codes	N