591778-70-0

591778-70-0 structure

Name: CP-640186 hydrochloride
Chemical Name: 9-Anthryl[(3R)-3-(4-morpholinylcarbonyl)-1,4'-bipiperidin-1'-yl]methanone hydrochloride (1:1)
CAS Number: 591778-70-0
Molecular Formula: C₃₀H₃₆ClN₃O₃
Molecular Weight: 522.078
Catalog: Signaling Pathways Metabolic Enzyme/Protease Acetyl-CoA Carboxylase
Create Date: 2018-02-11 08:00:00
Modify Date: 2024-01-11 09:11:17
CP-640186 hydrochloride is a potent and cell-permeable Acetyl-CoA carboxylase (ACC) inhibitor with IC50s of 53 nM and 61 nM for rat liver ACC1 and rat skeletal muscle ACC2 respectively.

Name	9-Anthryl[(3R)-3-(4-morpholinylcarbonyl)-1,4'-bipiperidin-1'-yl]methanone hydrochloride (1:1)
Synonyms	9-Anthryl[(3R)-3-(4-morpholinylcarbonyl)-1,4'-bipiperidin-1'-yl]methanone hydrochloride (1:1) Methanone, 9-anthracenyl[(3R)-3-(4-morpholinylcarbonyl)[1,4'-bipiperidin]-1'-yl]-, hydrochloride (1:1) CP-640186 hydrochloride CP-640186 (hydrochloride)

Description	CP-640186 hydrochloride is a potent and cell-permeable Acetyl-CoA carboxylase (ACC) inhibitor with IC50s of 53 nM and 61 nM for rat liver ACC1 and rat skeletal muscle ACC2 respectively.
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Acetyl-CoA Carboxylase Research Areas >> Metabolic Disease
References	[1]. Harwood HJ Jr, et al. Isozyme-nonselective N-substituted bipiperidylcarboxamide acetyl-CoA carboxylase inhibitors reduce tissue malonyl-CoA concentrations, inhibit fatty acid synthesis, and increase fatty acid oxidation in cultured cells and in experimental animals. J Biol Chem. 2003 Sep 26;278(39):37099-111. [2]. Yamashita T, et al. Design, synthesis, and structure-activity relationships of spirolactones bearing 2-ureidobenzothiophene as acetyl-CoA carboxylases inhibitors. Bioorg Med Chem Lett. 2011 Nov 1;21(21):6314-8.