261521-21-5

261521-21-5 structure

Name: PAR-3 (1-6) amide (mouse) trifluoroacetate salt
Chemical Name: L-Seryl-L-phenylalanyl-L-asparaginylglycylglycyl-L-prolinamide
CAS Number: 261521-21-5
Molecular Formula: C₂₅H₃₆N₈O₈
Molecular Weight: 576.60
Catalog: Signaling Pathways GPCR/G Protein Protease-Activated Receptor (PAR)
Create Date: 2018-07-14 03:23:08
Modify Date: 2024-01-02 09:26:16
SFNGGP-NH2 is a biological active peptide. (PAR-3 is a high-affinity thrombin receptor. PAR-3 mRNA is expressed in the cutaneous mast cells of humans. Protease-Activated Receptors (PARs) have been studied for their roles in itch and their itch-associated response through histamine-dependent/independent pathways have been reported. PAR-3 has been shown not to induce itching alone but possibly in conjunction with PAR-4. Co-expression of PAR-3 and PAR-4 enhances thrombin action suggesting that PAR-3 alone does not mediate transmembrane signaling but instead functions as a cofactor to activate PAR-4.)

Name	L-Seryl-L-phenylalanyl-L-asparaginylglycylglycyl-L-prolinamide
Synonyms	L-Seryl-L-phenylalanyl-L-asparaginylglycylglycyl-L-prolinamide L-Prolinamide, L-seryl-L-phenylalanyl-L-asparaginylglycylglycyl- SFNGGP-NH2 PAR3 Tethered Ligand (Murine) / Activates PAR1 and PAR2 PAR-3 (1-6) amide (mouse)

Description	SFNGGP-NH2 is a biological active peptide. (PAR-3 is a high-affinity thrombin receptor. PAR-3 mRNA is expressed in the cutaneous mast cells of humans. Protease-Activated Receptors (PARs) have been studied for their roles in itch and their itch-associated response through histamine-dependent/independent pathways have been reported. PAR-3 has been shown not to induce itching alone but possibly in conjunction with PAR-4. Co-expression of PAR-3 and PAR-4 enhances thrombin action suggesting that PAR-3 alone does not mediate transmembrane signaling but instead functions as a cofactor to activate PAR-4.)
Related Catalog	Research Areas >> Others Signaling Pathways >> GPCR/G Protein >> Protease-Activated Receptor (PAR)