305336-82-7

305336-82-7 structure

Name: Mca-Ala-Pro-Lys(Dnp)-OH
Chemical Name: Mca-APK(Dnp)
CAS Number: 305336-82-7
Molecular Formula: C₃₀H₃₄N₆O₁₀
Molecular Weight: 638.625
Catalog: Research Areas Others
Create Date: 2018-05-20 08:00:00
Modify Date: 2024-01-16 18:25:40
Mca-Ala-Pro-Lys(Dnp)-OH, a specific ACE2 quenched fluorogenic substrate, can be used to detect ACE2 activity, such as urinary, heart and lung[1][2].

Name	Mca-APK(Dnp)
Synonyms	N-(4-Methyl-2-oxo-2H-chromen-7-yl)-L-alanyl-L-prolyl-N-(2,4-dinitrophenyl)-L-lysine L-Lysine, N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-L-alanyl-L-prolyl-N-(2,4-dinitrophenyl)-

Description	Mca-Ala-Pro-Lys(Dnp)-OH, a specific ACE2 quenched fluorogenic substrate, can be used to detect ACE2 activity, such as urinary, heart and lung[1][2].
Related Catalog	Research Areas >> Others Signaling Pathways >> Others >> Others
In Vitro	The activity of ACE2 enzyme detected by: the fluorescent peptide substrate Mca-AlaPro-Lys (Dnp)-OH is hydrolyzed by ACE2 and its product is detected by the active fluorescence resonance energy transfer method[3].
References	[1]. Liu J, Ji H, et al. Sex differences in renal angiotensin converting enzyme 2 (ACE2) activity are 17β-oestradiol-dependent and sex chromosome-independent. Biol Sex Differ. 2010;1(1):6. Published 2010 Nov 5. [2]. Liang Y, et al. Urinary angiotensin converting enzyme 2 increases in patients with type 2 diabetic mellitus. Kidney Blood Press Res. 2015;40(2):101-110.