1628805-46-8

1628805-46-8 structure

Name: IDH-305
Chemical Name: IDH-305
CAS Number: 1628805-46-8
Molecular Formula: C₂₃H₂₂F₄N₆O₂
Molecular Weight: 490.46
Catalog: Signaling Pathways Metabolic Enzyme/Protease Isocitrate Dehydrogenase (IDH)
Create Date: 2018-06-27 15:24:45
Modify Date: 2024-01-11 17:38:53
IDH-305 is an inhibitor of isocitrate dehydrogenase (IDH).

Name	IDH-305
Synonyms	(4R)-4-[(1S)-1-fluoroethyl]-3-(2-{[(1S)-1-[4-methyl-2'-(trifluoromethyl)-[3,4'-bipyridin]-6-yl]ethyl]amino}pyrimidin-4-yl)-1,3-oxazolidin-2-one

Description	IDH-305 is an inhibitor of isocitrate dehydrogenase (IDH).
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Isocitrate Dehydrogenase (IDH) Research Areas >> Cancer
Target	IDH[1]
In Vitro	IDH-305 is an inhibitor of isocitrate dehydrogenase (IDH). Isocitrate dehydrogenase (IDH) is an essential enzyme for cellular respiration in the tricarboxylic acid (TCA) cycle. The IDH1 inhibitor IDH-305 has entered an ongoing phase 1 clinical trial (NCT02381886) for patients with IDH1-R132 mutant advanced hematologic or solid malignancies[1].
References	[1]. Fujii T,et al. Targeting isocitrate dehydrogenase (IDH) in cancer. Discov Med. 2016 May;21(117):373-80.