1218816-71-7

1218816-71-7 structure

Name: SK1-IN-1
Chemical Name: SK1-IN-1
CAS Number: 1218816-71-7
Molecular Formula: C₂₂H₃₀N₄O₃
Molecular Weight: 398.499
Catalog: Signaling Pathways Immunology/Inflammation SPHK
Create Date: 2018-02-18 02:19:58
Modify Date: 2024-01-24 12:29:05
SK1-IN-1 is a potent sphingosine kinase 1 (SPHK1) inhibitor with an IC50 of 58 nM.

Name	SK1-IN-1
Synonyms	(3S)-N-[(1S)-1-{4-[5-(2-Cyclopentylethyl)-1,2,4-oxadiazol-3-yl]phenyl}ethyl]-3-hydroxy-L-prolinamide 2-Pyrrolidinecarboxamide, N-[(1S)-1-[4-[5-(2-cyclopentylethyl)-1,2,4-oxadiazol-3-yl]phenyl]ethyl]-3-hydroxy-, (2S,3S)-

Description	SK1-IN-1 is a potent sphingosine kinase 1 (SPHK1) inhibitor with an IC50 of 58 nM.
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> SPHK Research Areas >> Cancer Research Areas >> Inflammation/Immunology
Target	IC50: 58 nM (SPHK1)[1]
In Vivo	SK1-IN-1 demonstrates significant improvement in the intrinsic clearance, particularly against human liver microsomes. SK1-IN-1 is selected for rat PK studies and demonstrates modest in oral bioavailability with acceptable half-lives in blood circulation[1].
References	[1]. Xiang Y, et al. Discovery of novel sphingosine kinase-1 inhibitors. Part 2. Bioorg Med Chem Lett. 2010 Aug 1;20(15):4550-4.