1428569-85-0
1428569-85-0 structure
- Name: GDC-0339
- Chemical Name: GDC-0339
- CAS Number: 1428569-85-0
- Molecular Formula: C20H22F3N7OS
- Molecular Weight: 465.495
- Catalog: Signaling Pathways JAK/STAT Signaling Pim
- Create Date: 2018-05-02 04:45:48
- Modify Date: 2024-01-03 08:05:28
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GDC-0339 is a Pim kinase inhibitor with IC50 of 43.6 nM for BaF3 PIM1.IC50 value: 43.6 nM (for BaF3 PIM1), 0.04 nM (Ki, for PIM1 LC-3K)Target: Pim
| Name | GDC-0339 |
|---|---|
| Synonyms |
4-Thiazolecarboxamide, 5-amino-N-[5-[(4R,5R)-4-amino-5-fluorohexahydro-1H-azepin-1-yl]-1-methyl-1H-pyrazol-4-yl]-2-(2,6-difluorophenyl)-
5-Amino-N-{5-[(4R,5R)-4-amino-5-fluoro-1-azepanyl]-1-methyl-1H-pyrazol-4-yl}-2-(2,6-difluorophenyl)-1,3-thiazole-4-carboxamide |
| Description | GDC-0339 is a Pim kinase inhibitor with IC50 of 43.6 nM for BaF3 PIM1.IC50 value: 43.6 nM (for BaF3 PIM1), 0.04 nM (Ki, for PIM1 LC-3K)Target: Pim |
|---|---|
| Related Catalog | |
| Cell Assay | BaF3, a murine interleukin-3 dependent pro-B cell line, parental cells, BaF3 PIM 1 cells, BaF3 PIM2 cells, and MM1.S (multiple myeloma) cells are seeded at 2 k/well, 5 k/well, 5k/well, 10 k/well, respectively, in a 384-well plate, at 45 μL/well. GDC-0339 is added at 5 μL/well. BaF3 cells (parental and transfected) are incubated over night, while MM1.S cells are incubated for 72 hours at 37°C, 5% CO2, CELL TITER GLO Reagent is added at 50 μL/well, the plates are incubated for 30 minutes, and their luminescence read on an HT Analyst. IC50/EC50 values for GDC-0339 is calculated[1]. |
| Density | 1.6±0.1 g/cm3 |
|---|---|
| Molecular Formula | C20H22F3N7OS |
| Molecular Weight | 465.495 |
| Exact Mass | 465.155853 |
| LogP | 0.43 |
| Index of Refraction | 1.715 |
| Storage condition | 2-8℃ |