1825355-56-3
1825355-56-3 structure
- Name: Ribocil-C
- Chemical Name: Ribocil-C
- CAS Number: 1825355-56-3
- Molecular Formula: C21H21N7OS
- Molecular Weight: 419.503
- Catalog: Research Areas Infection
- Create Date: 2018-03-27 19:32:11
- Modify Date: 2024-01-09 12:47:38
-
Ribocil-C is a highly selective inhibitor of bacterial riboflavin riboswitches.
| Name | Ribocil-C |
|---|---|
| Synonyms |
2-[(3S)-1-{[1-(2-Pyrimidinyl)-1H-imidazol-4-yl]methyl}-3-piperidinyl]-6-(2-thienyl)-4(1H)-pyrimidinone
4(1H)-Pyrimidinone, 2-[(3S)-1-[[1-(2-pyrimidinyl)-1H-imidazol-4-yl]methyl]-3-piperidinyl]-6-(2-thienyl)- |
| Description | Ribocil-C is a highly selective inhibitor of bacterial riboflavin riboswitches. |
|---|---|
| Related Catalog | |
| Target |
Bacterial riboflavin riboswitches[1] |
| In Vitro | Ribocil-C is a highly selective inhibitor of the flavin mononucleotide (FMN) riboswitch that controls expression of de novo riboflavin (RF, vitamin B2) biosynthesis in Escherichia coli. Ribocil-C specifically inhibits dual FMN riboswitches, separately controlling RF biosynthesis and uptake processes essential for Staphylococcus aureus growth and pathogenesis[1]. Ribocil-C is a small-molecule synthetic mimic of FMN that binds the FMN riboswitch of multiple GN bacteria, including Escherichia coli, Pseudomonas aeruginosa, and Acinetobacter baumannii, to inhibit ribB expression, RF synthesis, and consequently arrest bacterial growth[1][2]. |
| In Vivo | Higher dose Ribocil-C treatment groups (60 and 120 mg kg21 ribocil-C) demonstrate a dose-dependent reduction in bacterial burden of 1.87 and 3.29 log10[CFU per g spleen] reduction respectively versus shamtreated mice, without mortality or gross effects of toxicity observed[2]. |
| Animal Admin | DBA/2J mice are infected by intraperitoneal injectionwith Escherichia coli strain MB5746 (5×104 CFU per mouse) and treated by subcutaneous injection with Ribocil-C (30, 60, 120 mg/kg) or ciprofloxacin (0.5mg/kg) three times over a 24 h infection period. Spleens are aseptically collected from five mice per group and the reduction of log[CFU per g spleen tissue] is calculated on the basis of bacterial burden in spleens of the vehicle-treated (10% DMSO) control group[2]. |
| References |
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Boiling Point | 672.0±65.0 °C at 760 mmHg |
| Molecular Formula | C21H21N7OS |
| Molecular Weight | 419.503 |
| Flash Point | 360.2±34.3 °C |
| Exact Mass | 419.152832 |
| LogP | 1.25 |
| Vapour Pressure | 0.0±2.1 mmHg at 25°C |
| Index of Refraction | 1.771 |
| Storage condition | 2-8℃ |