Name | YM-58790 |
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Synonyms |
Carbamic acid, N-(diphenylmethyl)-, 1-[[4-(methylamino)phenyl]methyl]-4-piperidinyl ester, hydrochloride (1:1)
1-[4-(Methylamino)benzyl]-4-piperidinyl (diphenylmethyl)carbamate hydrochloride (1:1) |
Description | YM-58790 is a potent antagonist of M3 muscarinic receptor, with Ki of 15 nM. |
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Related Catalog | |
Target |
Ki: 15 nM (M3 muscarinic receptor)[1] |
In Vitro | YM-58790 shows potent inhibitory effect on urinary bladder contraction, but has little effect on bradycardia. YM-58790 exhibits selective antagonism between urinary bladder contraction and salivary secretion in vitro[1]. |
In Vivo | YM-58790 (3 mg/kg, i.v.) does not inhibit oxotremorine-induced tremor in mice. The effect of YM-58790 on McN-A343-induced pressor in pithed rats, as an indication of M1 antagonism in vivo, is much less potent than bladder contraction. YM-58790 exhibits potent inhibitory activity on bladder pressuer in reflexly-evoked rhythmic contraction, similar to oxybutynin, and has appr ten times less inhibitory effect on oxotremorine-induced salivary secretion than oxybutynin in rats[1]. |
References |
Molecular Formula | C27H32ClN3O2 |
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Molecular Weight | 466.015 |
Exact Mass | 465.218292 |
Storage condition | 2-8℃ |