63236-23-7

63236-23-7 structure

Name: Pareptide monohydrochloride
Chemical Name: Pareptide monohydrochloride
CAS Number: 63236-23-7
Molecular Formula: C₁₄H₂₇ClN₄O₃
Molecular Weight: 334.842
Catalog: Research Areas Neurological Disease
Create Date: 2018-01-06 03:55:16
Modify Date: 2024-01-12 12:37:58
Pareptide monohydrochloride is a melanotropin-inhibiting factor (MIF) metabolically stable analogue.

Name	Pareptide monohydrochloride
Synonyms	L-Prolyl-N-methylleucylglycinamide hydrochloride (1:1) Glycinamide, L-prolyl-N-methylleucyl-, hydrochloride (1:1) GC65JE8O95 PAREPTIDE HYDROCHLORIDE

Description	Pareptide monohydrochloride is a melanotropin-inhibiting factor (MIF) metabolically stable analogue.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease
In Vivo	Chronic coadministration of Pareptide (0.25 mg/kg, SC, BID, 3.5 days) to mice pretreated with Haloperidol (8.0 mg/kg, IP, BID, 3 days) significantly increases the cataleptic effects of a smaller challenge dose of Haloperidol (2.0 mg/kg, IP) given 15 hours after the last pretreatment injections (p<0.01)[1].
Animal Admin	Mice[1] Male albino mice of a Swiss-Webster derived strain and eighing from 26-34 g are used. Single doses of MIF-I (0.03-2.0 mg/kg, SC) and chronic pretreatments with MIF-I (0,03-2.0 mg/kg, SC, BID, 3.5 days) or Pareptide (0.25 mg/kg, SC, BID, 3.5 days) do not affect the acute cataleptic response to Haloperidol in the mouse. Pareptide is given SC in a 5 mL/kg injection volume. Chronic pretreatment with Haloperidol (8.0 mg/kg, IP, BID, 3 days) decreases the duration of catalepsy in mice given smaller challenge doses of Haloperidol (2.0 or 3.0 mg/kg, IP) 15 hours after the last pretreatment injections. Administration of either MIF-I or Pareptide to mice also chronically pretreated with Haloperidol antagonizes the development of tolerance[1].
References	[1]. Mycroft FJ, et al. Pro-Leu-Gly-NH2 and Pareptide inhibit development of tolerance to Haloperidol catalepsy in the mouse. Peptides. 1984 Sep-Oct;5(5):883-7.