63302-99-8

63302-99-8 structure

Name: Azaphen dihydrochloride monohydrate
Chemical Name: Azaphen dihydrochloride monohydrate
CAS Number: 63302-99-8
Molecular Formula: C₁₆H₂₃Cl₂N₅O₂
Molecular Weight: 388.292
Catalog: Signaling Pathways Neuronal Signaling Serotonin Transporter
Create Date: 2018-01-18 15:11:54
Modify Date: 2024-01-10 12:12:38
Pipofezine(Azafen or Azaphen) is a potent inhibitor of the reuptake of serotonin. IC50 Value: Target: SSRIsPipofezine is a tricyclic antidepressant (TCA) approved in Russia for the treatment ofdepression. In addition to its antidepressant action, pipofezine has sedative effects as well, indicating antihistamine activity.

Name	Azaphen dihydrochloride monohydrate
Synonyms	5H-Pyridazino[3,4-b][1,4]benzoxazine, 5-methyl-3-(4-methyl-1-piperazinyl)-, hydrochloride, hydrate (1:2:1) 5-Methyl-3-(4-methyl-1-piperazinyl)-5H-pyridazino[3,4-b][1,4]benzoxazine dihydrochloride hydrate MFCD00220368 5-methyl-3-(4-methylpiperazino)-5H-benzo[b]pyridazino[4,3-e][1,4]oxazine dihydrochloride hydrate Azaphen (dihydrochloride monohydrate)

Description	Pipofezine(Azafen or Azaphen) is a potent inhibitor of the reuptake of serotonin. IC50 Value: Target: SSRIsPipofezine is a tricyclic antidepressant (TCA) approved in Russia for the treatment ofdepression. In addition to its antidepressant action, pipofezine has sedative effects as well, indicating antihistamine activity.
Related Catalog	Signaling Pathways >> Neuronal Signaling >> Serotonin Transporter Research Areas >> Neurological Disease
References	[1]. Shinaev NN, Akzhigitov RG. Azaphen: a return to clinical practice.Zh Nevrol Psikhiatr Im S S Korsakova. 2005;105(10):55-6. [2]. Ignatowicz L, Ignatowicz R, Wdowiak MW, Jaremko A. Azaphen in the treatment of enuresis in children.Psychiatr Pol. 1977 Jan-Feb;11(1):29-33. [3]. Liberman SS, Sharova SA. A comparison of the effect of the tricyclic antidepressants azaphen and imizin on the gastrointestinal tracts of experimental animals.Farmakol Toksikol. 1975 Jan-Feb;38(1):29-32. [4]. Misurec J, Náhunek K, Kamenická V, Chmelar M. Proceedings: Influence of azaphen, a new antidepressive drug, on the human EEG. Act Nerv Super (Praha). 1974;16(4):245-6.