Shanghai Nianxing Industrial Co., Ltd
China
Product Name: (1R,2R)-2-PCCA2HCl
Price:
Purity: 98.0%
Stocking Period: 10 Day
Contact: Huang

1609563-71-4

1609563-71-4 structure

1609563-71-4 structure

Name: (1R,2R)-2-PCCA(hydrochloride)
Chemical Name: (1R,2R)-2-PCCA(hydrochloride)
CAS Number: 1609563-71-4
Molecular Formula: C₃₀H₃₉Cl₂N₃O
Molecular Weight: 528.56
Catalog: Research Areas Neurological Disease
Create Date: 2018-05-28 05:38:01
Modify Date: 2024-02-29 19:56:51
(1R,2R)-2-PCCA hydrochloride is a diastereomer of 2-PCCA, and acts as a potent GPR88 receptor agonist, with an EC50 of 3 nM.

Name	(1R,2R)-2-PCCA(hydrochloride)

Description	(1R,2R)-2-PCCA hydrochloride is a diastereomer of 2-PCCA, and acts as a potent GPR88 receptor agonist, with an EC50 of 3 nM.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease
Target	EC50: 3 nM (GPR88 receptor)[1]
In Vitro	(1R,2R)-2-PCCA hydrochloride is a potent GPR88 receptor agonist, with an EC50 of 3 nM[1]. (1R,2R)-2-PCCA inhibits GPR88-mediated cAMP production through a Gαi-coupled pathway, with an EC50 of 56 nM in HEK293 cells stably expressing the human GPR88 receptor and the GloSensor-22F cAMP construct[2].
References	[1]. Bi, Yingzhi, et al. Modulators of G Protein-Coupled Receptor 88. US 20110251204 A1. [2]. Jin C, et al. Effect of Substitution on the Aniline Moiety of the GPR88 Agonist 2-PCCA: Synthesis, Structure-Activity Relationships, and Molecular Modeling Studies. ACS Chem Neurosci. 2016 Oct 19;7(10):1418-1432.

Molecular Formula	C₃₀H₃₉Cl₂N₃O
Molecular Weight	528.56