Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Veratric acid-d6
Price:
Purity: 98.0%
Stocking Period: 10 Day
Contact: Yang

1162658-12-9

1162658-12-9 structure

Name: Veratric acid-d6
Chemical Name: 3,4-Bis[(2H3)methyloxy]benzoic acid
CAS Number: 1162658-12-9
Molecular Formula: C₉H₄D₆O₄
Molecular Weight: 188.21
Catalog: Signaling Pathways Immunology/Inflammation COX
Create Date: 2018-07-05 12:50:48
Modify Date: 2024-01-12 09:19:17
Veratric acid-d6 is deuterium labeled Veratric acid. Veratric acid (3,4-Dimethoxybenzoic acid) is an orally active phenolic compound derived from vegetables and fruits, has antioxidant[1] and anti-inflammatory activities[3]. Veratric acid also acts as a protective agent against hypertension-associated cardiovascular remodelling[2]. Veratric acid reduces upregulated COX-2 expression, and levels of PGE2, IL-6 after UVB irradiation[3].

Name	3,4-Bis[(2H3)methyloxy]benzoic acid
Synonyms	Benzoic acid, 3,4-bis(methyl-d3-oxy)- 3,4-Bis[(2H3)methyloxy]benzoic acid

Description	Veratric acid-d6 is deuterium labeled Veratric acid. Veratric acid (3,4-Dimethoxybenzoic acid) is an orally active phenolic compound derived from vegetables and fruits, has antioxidant[1] and anti-inflammatory activities[3]. Veratric acid also acts as a protective agent against hypertension-associated cardiovascular remodelling[2]. Veratric acid reduces upregulated COX-2 expression, and levels of PGE2, IL-6 after UVB irradiation[3].
Related Catalog	Research Areas >> Cardiovascular Disease Research Areas >> Inflammation/Immunology Signaling Pathways >> Immunology/Inflammation >> COX
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Choi WS, et al. Veratric acid inhibits iNOS expression through the regulation of PI3K activation and histone acetylation in LPS-stimulated RAW264.7 cells. Int J Mol Med. 2015 Jan;35(1):202-10. [3]. Saravanakumar M, et al. Oral administration of veratric acid, a constituent of vegetables and fruits, prevents cardiovascular remodelling in hypertensive rats: a functional evaluation. Br J Nutr. 2015 Nov 14;114(9):1385-94. [4]. Shin SW, et al. Antagonist effects of veratric acid against UVB-induced cell damages. Molecules. 2013 May 10;18(5):5405-19.

Density	1.2±0.1 g/cm3
Boiling Point	302.9±22.0 °C at 760 mmHg
Molecular Formula	C₉H₄D₆O₄
Molecular Weight	188.21
Flash Point	120.9±15.8 °C
Exact Mass	188.095566
LogP	1.99
Vapour Pressure	0.0±0.7 mmHg at 25°C
Index of Refraction	1.533

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