158732-55-9

158732-55-9 structure

Name: Escin IIa
Chemical Name: 82XHO27XQ8
CAS Number: 158732-55-9
Molecular Formula: C₅₄H₈₄O₂₃
Molecular Weight: 1101.231
Catalog: Research Areas Inflammation/Immunology
Create Date: 2018-07-04 20:54:41
Modify Date: 2024-01-05 15:18:47
Escin IIa, isolated from horse chestnut, the seeds of Aesculus hippocastanum L., has positive effects on acute inflammation in animals. Escin IIa has gastroprotections on ethanol-induced gastric mucosal lesions in rats[1][2].

Name	82XHO27XQ8
Synonyms	(3β,16α,21β,22α)-22-Acetoxy-16,24,28-trihydroxy-21-{[(2E)-2-methyl-2-butenoyl]oxy}olean-12-en-3-yl β-D-glucopyranosyl-(1->4)-[β-D-xylopyranosyl-(1->2)]-β-D-glucopyranosiduronic acid 2-butenoic acid, 2-methyl-, (3β,16α,21β,22α)-22-(acetyloxy)-3-[[O-β-D-glucopyranosyl-(1->4)-O-[β-D-xylopyranosyl-(1->2)]-β-D-glucopyranuronosyl]oxy]-16,24,28-trihydroxyolean-12-en-21-yl ester, (2E)- 82XHO27XQ8 MFCD10566614 (3β,16α,21β,22α)-22-Acetoxy-16,24,28-trihydroxy-21-{[(2E)-2-methylbut-2-enoyl]oxy}olean-12-en-3-yl β-D-glucopyranosyl-(1->4)-[β-D-xylopyranosyl-(1->2)]-β-D-glucopyranosiduronic acid 2-Butenoic acid, 2-methyl-, (3β,16α,21β,22α)-22-(acetyloxy)-3-[[O-β-D-glucopyranosyl-(1->4)-O-[β-D-xylopyranosyl-(1->2)]-β-D-glucopyranuronosyl]oxy]-16,24,28-trihydroxyolean-12- en-21-yl ester, (2E)-

Description	Escin IIa, isolated from horse chestnut, the seeds of Aesculus hippocastanum L., has positive effects on acute inflammation in animals. Escin IIa has gastroprotections on ethanol-induced gastric mucosal lesions in rats[1][2].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology
In Vivo	Escins Ia, Ib, IIa, and IIb (50-200 mg/kg) inhibits the increase of vascular permeability induced by both acetic acid in mice and histamine in rats. Escins Ib, IIa, and IIb (50-200 mg/kg) also inhibit that induced by serotonin in rats, but escin Ia didn't. Escins Ia, Ib, IIa, and IIb (200 mg/kg) inhibit the hind paw edema induced by carrageenin at the first phase in rats. Escin Ia (200 mg/kg) and escins Ib, IIa, and IIb (50-200 mg/kg) inhibit the scratching behavior induced by compound 48/80 in mice, but escin Ia was weakest[1]. Escin IIa (10-50 mg/kg;p.o.;) potently inhibits ethanol-induced gastric mucosal lesions[2]. Animal Model: Male Sprague–Dawley rats (Ethanol-induced gastric mucosal lesions in rats)[1] Dosage: 10-50 mg/kg Administration: p.o. Result: Showed a potent protective effect against ethanol-induced gastric lesions in rats.
References	[1]. Matsuda H, et al. Effects of escins Ia, Ib, IIa, and IIb from horse chestnut, the seeds of Aesculus hippocastanum L., on acute inflammation in animals. Biol Pharm Bull. 1997;20(10):1092-1095. [2]. Matsuda H, et al. Gastroprotections of escins Ia, Ib, IIa, and IIb on ethanol-induced gastric mucosal lesions in rats. Eur J Pharmacol. 1999;373(1):63-70.

Density	1.5±0.1 g/cm3
Boiling Point	1111.9±65.0 °C at 760 mmHg
Molecular Formula	C₅₄H₈₄O₂₃
Molecular Weight	1101.231
Flash Point	305.5±27.8 °C
Exact Mass	1100.540283
LogP	4.87
Vapour Pressure	0.0±0.6 mmHg at 25°C
Index of Refraction	1.624

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