1253641-65-4

1253641-65-4 structure

Name: TM 38837
Chemical Name: TM-38837
CAS Number: 1253641-65-4
Molecular Formula: C₃₀H₂₅Cl₂F₃N₄OS
Molecular Weight: 617.512
Catalog: Signaling Pathways GPCR/G Protein Cannabinoid Receptor
Create Date: 2018-06-10 01:07:07
Modify Date: 2024-02-03 02:18:51
TM38837 is a peripheral selective cannabinoid receptor type 1 (CB1) receptor antagonist. TM38837 shows limited penetrance to the brain in order to minimize or prevent CNS adverse reactions, and preserves potential antiobesity effects. TM38837 reduces propensity for psychiatric side effects[1][2].

Name	TM-38837
Synonyms	1H-Pyrazole-3-carboxamide, 1-(2,4-dichlorophenyl)-4-ethyl-N-1-piperidinyl-5-[5-[2-[4-(trifluoromethyl)phenyl]ethynyl]-2-thienyl]- 1-(2,4-Dichlorophenyl)-4-ethyl-N-(1-piperidinyl)-5-(5-{[4-(trifluoromethyl)phenyl]ethynyl}-2-thienyl)-1H-pyrazole-3-carboxamide TM-38837

Description	TM38837 is a peripheral selective cannabinoid receptor type 1 (CB1) receptor antagonist. TM38837 shows limited penetrance to the brain in order to minimize or prevent CNS adverse reactions, and preserves potential antiobesity effects. TM38837 reduces propensity for psychiatric side effects[1][2].
Related Catalog	Research Areas >> Metabolic Disease Signaling Pathways >> GPCR/G Protein >> Cannabinoid Receptor
Target	CB1
In Vivo	TM38837 (10-100 mg/kg; p.o.) induces a significant increase in freezing behavior at 100 mg/kg[1]. Animal Model: 7-8 weeks old male C57BL/6 N mice (B6N)[1] Dosage: 10, 30, or 100 mg/kg Administration: p.o. Result: High dose (100 mg/kg) induced a significant increase in freezing behavior.
References	[1]. Micale V, et al. The Cannabinoid CB1 Antagonist TM38837 With Limited Penetrance to the Brain Shows ReducedFear-Promoting Effects in Mice. Front Pharmacol. 2019 Mar 20;10:207. [2]. Klumpers LE, et al. Peripheral selectivity of the novel cannabinoid receptor antagonist TM38837 in healthy subjects. Br J Clin Pharmacol. 2013 Dec;76(6):846-57.