613225-56-2

613225-56-2 structure

Name: F1063-0967
Chemical Name: 2-Hydroxy-4-({6-[(5Z)-5-(4-methylbenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]hexanoyl}amino)benzoic acid
CAS Number: 613225-56-2
Molecular Formula: C₂₄H₂₄N₂O₅S₂
Molecular Weight: 484.588
Catalog: Signaling Pathways Metabolic Enzyme/Protease Phosphatase
Create Date: 2018-07-01 10:27:45
Modify Date: 2024-09-02 15:49:37
F1063-0967 is a Dual-specificity phosphatase 26 (DUSP26) inhibitor with an IC50 of 11.62 μM.

Name	2-Hydroxy-4-({6-[(5Z)-5-(4-methylbenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]hexanoyl}amino)benzoic acid
Synonyms	Benzoic acid, 2-hydroxy-4-[[6-[(5Z)-5-[(4-methylphenyl)methylene]-4-oxo-2-thioxo-3-thiazolidinyl]-1-oxohexyl]amino]- MFCD04423481 2-Hydroxy-4-({6-[(5Z)-5-(4-methylbenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]hexanoyl}amino)benzoic acid F1063-0967

Description	F1063-0967 is a Dual-specificity phosphatase 26 (DUSP26) inhibitor with an IC50 of 11.62 μM.
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphatase Research Areas >> Cancer
Target	IC50: 11.62 μM (DUSP26)[1]
In Vitro	F1063-0967 is a Dual-specificity phosphatase 26 (DUSP26) inhibitor with an IC50 of 11.62 μM. At concentration above 0.1 μM, F1063-0967 remarkably induces IMR32 cell apoptosis. F1063-0967 induces apoptosis in IMR-32 cell line with an IC50 value of 4.13 μM. F1063-0967 has no effect on HL7702 cell line, and little inhibition effect on SH-SY5Y cell line[1].
Cell Assay	The IMR-32 cells are plated in 96-well plates with 1×103 cells per well. After the cells are allowed to settle for 24 h, F1063-0967 (0, 10, 1, and 0.1 μM) is added. An MTTassay is performed. For cell lines HL7702 and SH-SY5Y, the cells are allowed to settle for 24 h, F1063-0967 (10 μM) is added, then MTT assays are carried out after 72 h[1].
References	[1]. Ren JX, et al. Identification of novel dual-specificity phosphatase 26 inhibitors by a hybrid virtual screening approach based on pharmacophore and molecular docking. Biomed Pharmacother. 2017 May;89:376-385.