202925-60-8

202925-60-8 structure

Name: conantokin R
Chemical Name: Glycyl-L-α-glutamyl-4-carboxy-L-α-glutamyl-4-carboxy-L-α-glutamyl-L-valyl-L-alanyl-L-lysyl-L-methionyl-L-alanyl-L-alanyl-4-carboxy-L-α-glutamyl-L-leucyl-L-alanyl-L-arginyl-4-carboxy-L-α-glutamyl-L-asparaginyl-L-isoleucyl-L-alanyl-L-lysyl-N-[(4R,7S,10S,13S,16R)-13-(4-aminobutyl)-7-(2-amino-2-oxoethyl)-4-{[(2S)-1-[(2S)-2-carboxy-1-pyrrolidinyl]-3-(4-hydroxyphenyl)-1-oxo-2-propanyl]carbamoyl}-10-isopropyl-6,9,12,15-tetraoxo
CAS Number: 202925-60-8
Molecular Formula: C₁₂₇H₂₀₁N₃₅O₄₉S₃
Molecular Weight: 3098.35
Catalog: Signaling Pathways Membrane Transporter/Ion Channel iGluR
Create Date: 2018-06-17 19:20:58
Modify Date: 2024-01-04 10:38:06
Conantokin R (Con-R) is an NMDA receptor peptide antagonist with an IC50 of 93 nM. Conantokin R binds Zn2+ and Mg2+ with Kds of 0.15 μM and 6.5 μM, respectively. Conantokin R shows anticonvulsant activity[1][2].

Name	Glycyl-L-α-glutamyl-4-carboxy-L-α-glutamyl-4-carboxy-L-α-glutamyl-L-valyl-L-alanyl-L-lysyl-L-methionyl-L-alanyl-L-alanyl-4-carboxy-L-α-glutamyl-L-leucyl-L-alanyl-L-arginyl-4-carboxy-L-α-glutamyl-L-asparaginyl-L-isoleucyl-L-alanyl-L-lysyl-N-[(4R,7S,10S,13S,16R)-13-(4-aminobutyl)-7-(2-amino-2-oxoethyl)-4-{[(2S)-1-[(2S)-2-carboxy-1-pyrrolidinyl]-3-(4-hydroxyphenyl)-1-oxo-2-propanyl]carbamoyl}-10-isopropyl-6,9,12,15-tetraoxo
Synonyms	Glycinamide, glycyl-L-α-glutamyl-4-carboxy-L-α-glutamyl-4-carboxy-L-α-glutamyl-L-valyl-L-alanyl-L-lysyl-L-methionyl-L-alanyl-L-alanyl-4-carboxy-L-α-glutamyl-L-leucyl-L-alanyl-L-arginyl -4-carboxy-L-α-glutamyl-L-asparaginyl-L-isoleucyl-L-alanyl-L-lysyl-N-[(4R,7S,10S,13S,16R)-13-(4-aminobutyl)-7-(2-amino-2-oxoethyl)-4-[[[(1S)-2-[(2S)-2-carboxy-1-pyrrolidinyl]-1-[(4-hydroxyphenyl)m ;ethyl]-2-oxoethyl]amino]carbonyl]-10-(1-meth Glycyl-L-α-glutamyl-4-carboxy-L-α-glutamyl-4-carboxy-L-α-glutamyl-L-valyl-L-alanyl-L-lysyl-L-methionyl-L-alanyl-L-alanyl-4-carboxy-L-α-glutamyl-L-leucyl-L-alanyl-L-arginyl-4-carboxy-L- α-glutamyl-L-asparaginyl-L-isoleucyl-L-alanyl-L-lysyl-N-[(4R,7S,10S,13S,16R)-13-(4-aminobutyl)-7-(2-amino-2-oxoethyl)-4-{[(2S)-1-[(2S)-2-carboxy-1-pyrrolidinyl]-3-(4-hydroxyphenyl)-1-oxo-2-propany ;l]carbamoyl}-10-isopropyl-6,9,12,15-tetraoxo

Description	Conantokin R (Con-R) is an NMDA receptor peptide antagonist with an IC50 of 93 nM. Conantokin R binds Zn2+ and Mg2+ with Kds of 0.15 μM and 6.5 μM, respectively. Conantokin R shows anticonvulsant activity[1][2].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> iGluR Research Areas >> Neurological Disease Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR
Target	IC50: 93 nM (NMDA receptor)[1]
References	[1]. Blandl T, et al. Structure-function relationships of the NMDA receptor antagonist peptide, conantokin-R. FEBS Lett. 2000 Mar 24;470(2):139-46. [2]. White HS, et al. In vitro and in vivo characterization of conantokin-R, a selective NMDA receptor antagonist isolated from the venom of the fish-hunting snail Conus radiatus. J Pharmacol Exp Ther. 2000 Jan;292(1):425-32.