1216796-18-7

1216796-18-7 structure

Name: Amiloride-15N3 hydrochloride
Chemical Name: 3,5-Diamino-N-(15N2)carbamimidoyl-6-chloro-2-pyrazine(15N)carboxamide hydrochloride (1:1)
CAS Number: 1216796-18-7
Molecular Formula: C₆H₉Cl₂N₄₁₅N₃O
Molecular Weight: 269.068
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2018-06-05 14:17:11
Modify Date: 2024-04-01 08:30:14
Amiloride-15N3 (hydrochloride) is the 15N labeled Amiloride hydrochloride[1]. Amiloride hydrochloride (MK-870 hydrochloride) is an inhibitor of both epithelial sodium channel (ENaC[2]) and urokinase-type plasminogen activator receptor (uTPA[3]). Amiloride hydrochloride is a blocker of polycystin-2 (PC2;TRPP2[4]) channel.

Name	3,5-Diamino-N-(15N2)carbamimidoyl-6-chloro-2-pyrazine(15N)carboxamide hydrochloride (1:1)
Synonyms	2-Pyrazinecarboxamide-15N, 3,5-diamino-N-(amino-15Nimino-15N-methyl)-6-chloro-, hydrochloride (1:1) 3,5-Diamino-N-(15N2)carbamimidoyl-6-chloro-2-pyrazine(15N)carboxamide hydrochloride (1:1)

Description	Amiloride-15N3 (hydrochloride) is the 15N labeled Amiloride hydrochloride[1]. Amiloride hydrochloride (MK-870 hydrochloride) is an inhibitor of both epithelial sodium channel (ENaC[2]) and urokinase-type plasminogen activator receptor (uTPA[3]). Amiloride hydrochloride is a blocker of polycystin-2 (PC2;TRPP2[4]) channel.
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> Sodium Channel Signaling Pathways >> Apoptosis >> Apoptosis Signaling Pathways >> Membrane Transporter/Ion Channel >> TRP Channel
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [2]. Ji, H.L., et al. delta ENaC: a novel divergent amiloride-inhibitable sodium channel. Am J Physiol Lung Cell Mol Physiol, 2012. 303(12): p. L1013-26. [3]. Teiwes J, et al. Epithelial sodium channel inhibition in cardiovascular disease. A potential role for amiloride. Am J Hypertens. 2007 Jan20(1):109-17. [4]. Giamarchi A, et al. A polycystin-2 (TRPP2) dimerization domain essential for the function of heteromeric polycystin complexes. EMBO J. 2010 Apr 729(7):1176-91.