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464924-27-4

464924-27-4 structure
464924-27-4 structure
  • Name: SLLK, Control Peptide for TSP1 Inhibitor
  • Chemical Name: (2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-1,3-dihydroxy-propylidene]amino]-1-hydroxy-4-methyl-pentylidene]amino]-1-hydroxy-4-methyl-pentylidene]amino]hexanoic acid
  • CAS Number: 464924-27-4
  • Molecular Formula: C21H41N5O6
  • Molecular Weight: 459.580
  • Catalog: Peptides
  • Create Date: 2018-06-09 15:43:13
  • Modify Date: 2024-01-08 23:28:40
  • SLLK, Control Peptide for TSP1 Inhibitor is a control peptide for LSKL (leucine-serine-lysine-leucine).

Name (2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-1,3-dihydroxy-propylidene]amino]-1-hydroxy-4-methyl-pentylidene]amino]-1-hydroxy-4-methyl-pentylidene]amino]hexanoic acid
Description SLLK, Control Peptide for TSP1 Inhibitor is a control peptide for LSKL (leucine-serine-lysine-leucine).
Related Catalog
In Vivo TGF-β1 is significantly lower (0.10±0.01 pg/mL) in the plasma of mice receiving LSKL compared with that in plasma of mice receiving SLLK control peptide at day 42 (0.20±0.02 pg/mL; P=0.0001). mRNA expression is assessed in the suprarenal aortic lysates obtained from mice receiving SLLK and LSKL peptides[1]. Akita mice treated with 30 mg/kg LSKL have significantly increased nephrin expression, greater than twofold, compared with renal lysates from either saline controls or SLLK-treated mice[2].
Animal Admin Sterile solutions of LSKL or SLLK peptide are made in stock solutions of 3.0 mg/mL (high dose) or 0.3 mg/mL (low dose) in sterile saline. The i.p. injection of LSKL, SLLK, or saline began 2 weeks after uninephrectomy and continues thrice weekly for 15 weeks. For the low-dosage treatment regimen, each group of 20 mice receives 3 mg/kg body weight of peptide (LSKL or SLLK) per injection or saline (100 μL/10 g body weight per injection). For the high-dosage treatment regimen, Akita mice ae given i.p. injections of LSKL or SLLK peptide at 30 mg/kg body weight per injection or saline (100 μL/10 g body weight per injection).
References

[1]. Krishna SM, et al. A peptide antagonist of thrombospondin-1 promotes abdominal aortic aneurysm progression in the angiotensin II-infused apolipoprotein-E-deficient mouse. Arterioscler Thromb Vasc Biol. 2015 Feb;35(2):389-98.

[2]. Lu A, et al. Blockade of TSP1-dependent TGF-β activity reduces renal injury and proteinuria in a murine model of diabetic nephropathy. Am J Pathol. 2011 Jun;178(6):2573-86.

Density 1.3±0.1 g/cm3
Boiling Point 690.1±65.0 °C at 760 mmHg
Molecular Formula C21H41N5O6
Molecular Weight 459.580
Flash Point 371.2±34.3 °C
Exact Mass 459.305695
LogP 2.91
Vapour Pressure 0.0±4.9 mmHg at 25°C
Index of Refraction 1.565
Storage condition 2-8℃