70754-23-3

70754-23-3 structure

Name: Delta (Phospho) Sleep Inducing Peptide
Chemical Name: L-Tryptophyl-L-alanylglycylglycyl-L-α-aspartyl-L-alanyl-O-phosphono-L-serylglycyl-L-glutamic acid
CAS Number: 70754-23-3
Molecular Formula: C₃₅H₄₉N₁₀O₁₈P
Molecular Weight: 928.794
Catalog: Research Areas Neurological Disease
Create Date: 2018-06-13 22:14:34
Modify Date: 2024-02-25 23:35:53
Delta (Phospho) Sleep Inducing Peptide (DSIP-P) is a long-lasting sleep-promoting peptide. Delta (Phospho) Sleep Inducing Peptide induces changes in the circadian locomotor behavior in rats[1][2][3].

Name	L-Tryptophyl-L-alanylglycylglycyl-L-α-aspartyl-L-alanyl-O-phosphono-L-serylglycyl-L-glutamic acid
Synonyms	L-Tryptophyl-L-alanylglycylglycyl-L-α-aspartyl-L-alanyl-O-phosphono-L-serylglycyl-L-glutamic acid L-Glutamic acid, L-tryptophyl-L-alanylglycylglycyl-L-α-aspartyl-L-alanyl-O-phosphono-L-serylglycyl-

Description	Delta (Phospho) Sleep Inducing Peptide (DSIP-P) is a long-lasting sleep-promoting peptide. Delta (Phospho) Sleep Inducing Peptide induces changes in the circadian locomotor behavior in rats[1][2][3].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease
In Vitro	Delta (Phospho) Sleep Inducing Peptide (20-300 nM) increases rat pineal N-acetyltransferase (NAT) activity induced by norepinephrine in vitro[3].
In Vivo	Delta (Phospho) Sleep Inducing Peptide (0.1 nmol/kg; i.v.; once daily for 4 times) induces changes in the circadian locomotor behavior[1]. Delta (Phospho) Sleep Inducing Peptide (20 or 200 pmol/kg; inject into the 3rd cerebroventricle of male rats immediately before the onset of the dark period) increases slow-wave sleep and paradoxical sleep during the subsequent dark period without shortening sleep latency at a dose of 200 pmol/kg[2]. Animal Model: Female rats from own inbred strain (KBS/K60)[1] Dosage: 0.1 nmol/kg Administration: Intravenous injection; once daily for 4 consecutive days Result: Induced rapid and mark changes in the circadian locomotor behavior when during the light (sleeping) phase testing animals became relatively more active.
References	[1]. Graf M, et al. Effects of repeated DSIP and DSIP-P administration on the circadian locomotor activity of rats. Pharmacol Biochem Behav. 1981 Nov;15(5):717-21. [2]. Nakagaki K, et al. Sleep-promoting effect following intracerebroventricular injection of a phosphorylated analogue of delta sleep-inducing peptide (DSIP-P) in rats. Neurosci Lett. 1988 Aug 31;91(2):160-4. [3]. Graf MV, Schoenenberger GA. Delta sleep-inducing peptide modulates the stimulation of rat pineal N-acetyltransferase activity by involving the alpha 1-adrenergic receptor. J Neurochem. 1987 Apr;48(4):1252-7.

Density	1.5±0.1 g/cm3
Molecular Formula	C₃₅H₄₉N₁₀O₁₈P
Molecular Weight	928.794
Exact Mass	928.296387
LogP	-4.17
Index of Refraction	1.614

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