1334172-58-5

1334172-58-5 structure

Name: Biotin-PEG4-PFP ester
Chemical Name: Pentafluorophenyl 17-oxo-21-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]-4,7,10,13-tetraoxa-16-azahenicosan-1-oate
CAS Number: 1334172-58-5
Molecular Formula: C₂₇H₃₆F₅N₃O₈S
Molecular Weight: 657.647
Catalog: Signaling Pathways Antibody-drug Conjugate ADC Linker
Create Date: 2018-06-09 09:23:49
Modify Date: 2024-01-10 03:28:24
Biotin-PEG4-PFP ester is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

Name	Pentafluorophenyl 17-oxo-21-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]-4,7,10,13-tetraoxa-16-azahenicosan-1-oate
Synonyms	Pentafluorophenyl 17-oxo-21-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]-4,7,10,13-tetraoxa-16-azahenicosan-1-oate 4,7,10,13-Tetraoxa-16-azaheneicosan-1-oic acid, 21-[(3aS,4S,6aR)-hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-4-yl]-17-oxo-, 2,3,4,5,6-pentafluorophenyl ester

Description	Biotin-PEG4-PFP ester is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker
Target	Cleavable
In Vitro	ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].
References	[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.