1360705-96-9
1360705-96-9 structure
- Name: ML 210
- Chemical Name: {4-[Bis(4-chlorophenyl)methyl]-1-piperazinyl}(5-methyl-4-nitro-1,2-oxazol-3-yl)methanone
- CAS Number: 1360705-96-9
- Molecular Formula: C22H20Cl2N4O4
- Molecular Weight: 475.325
- Catalog: Research Areas Cancer
- Create Date: 2018-06-25 13:05:55
- Modify Date: 2024-01-02 20:18:49
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ML-210，the most potent compound in the nitroisoxazole series， is a selective covalent inhibitor of glutathione peroxidase 4 (GPX4) by binding the selenocysteine residue[1]. ML-210 has IC50s of 71 nM, 272 nM and 107nM for BJeLR (HRASV12), BJeH-LT (without HRASV12) and DRD cell lines, respectively[2].
| Name | {4-[Bis(4-chlorophenyl)methyl]-1-piperazinyl}(5-methyl-4-nitro-1,2-oxazol-3-yl)methanone |
|---|---|
| Synonyms |
T6N DNTJ AYR DG&R DG& DV- ET5NOJ C1 DNW
MFCD22666407 Methanone, [4-[bis(4-chlorophenyl)methyl]-1-piperazinyl](5-methyl-4-nitro-3-isoxazolyl)- [4-[Bis(4-chlorophenyl)methyl]-1-piperazinyl]-(5-methyl-4-nitro-3-isoxazolyl)methanone {4-[Bis(4-chlorophenyl)methyl]-1-piperazinyl}(5-methyl-4-nitro-1,2-oxazol-3-yl)methanone |
| Description | ML-210，the most potent compound in the nitroisoxazole series， is a selective covalent inhibitor of glutathione peroxidase 4 (GPX4) by binding the selenocysteine residue[1]. ML-210 has IC50s of 71 nM, 272 nM and 107nM for BJeLR (HRASV12), BJeH-LT (without HRASV12) and DRD cell lines, respectively[2]. |
|---|---|
| Related Catalog | |
| Target |
Glutathione Peroxidase 4 (GPX4)[1] |
| References |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 644.7±55.0 °C at 760 mmHg |
| Molecular Formula | C22H20Cl2N4O4 |
| Molecular Weight | 475.325 |
| Flash Point | 343.7±31.5 °C |
| Exact Mass | 474.086151 |
| LogP | 2.39 |
| Vapour Pressure | 0.0±1.9 mmHg at 25°C |
| Index of Refraction | 1.636 |
