878978-76-8
878978-76-8 structure
- Name: ML-098
- Chemical Name: 1-[2-(2,5-Dimethylphenoxy)ethyl]-1H-indole-3-carboxylic acid
- CAS Number: 878978-76-8
- Molecular Formula: C19H19NO3
- Molecular Weight: 309.359
- Catalog: Signaling Pathways GPCR/G Protein Ras
- Create Date: 2016-11-28 07:01:42
- Modify Date: 2024-01-12 19:42:57
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ML-098 (CID-7345532) is an activator of the GTP-binding protein Rab7 with an EC50 of 77.6 nM.
| Name | 1-[2-(2,5-Dimethylphenoxy)ethyl]-1H-indole-3-carboxylic acid |
|---|---|
| Synonyms |
1-[2-(2,5-Dimethylphenoxy)ethyl]-1H-indole-3-carboxylic acid
1H-Indole-3-carboxylic acid, 1-[2-(2,5-dimethylphenoxy)ethyl]- ML-098 |
| Description | ML-098 (CID-7345532) is an activator of the GTP-binding protein Rab7 with an EC50 of 77.6 nM. |
|---|---|
| Related Catalog | |
| Target |
EC50: 77.6 nM (Rab7)[1] |
| In Vitro | Probe compound mL098 (CID-7345532) functions by increasing the affinity of the GTPases for guanine nucleotides, leading to the hypothesis that these activators interact with GTPases bind to an allosteric binding site localized between switch regions I and II. ML-098 is an activator of the GTP-binding protein Rab7 with an EC50 of 77.6 nM which shows selectivity against the related GTPases cdc42, Ras, Rab-2A, and Rac1 (EC50s = 588.8, 346.7, 158.5, and 794.3 nM, respectively)[1]. |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 535.5±45.0 °C at 760 mmHg |
| Molecular Formula | C19H19NO3 |
| Molecular Weight | 309.359 |
| Flash Point | 277.7±28.7 °C |
| Exact Mass | 309.136505 |
| PSA | 51.46000 |
| LogP | 4.96 |
| Vapour Pressure | 0.0±1.5 mmHg at 25°C |
| Index of Refraction | 1.593 |
| Storage condition | 2-8℃ |