1445379-59-8

1445379-59-8 structure

Name: 3'-O-(t-Butyldimethylsilyl)-2'-deoxy-2'-fluorouridine
Chemical Name: 2'-Deoxy-3'-O-[dimethyl(2-methyl-2-propanyl)silyl]-2'-fluorouridine
CAS Number: 1445379-59-8
Molecular Formula: C₁₅H₂₅FN₂O₅Si
Molecular Weight: 360.45
Catalog: Signaling Pathways Cell Cycle/DNA Damage Nucleoside Antimetabolite/Analog
Create Date: 2018-06-22 17:37:59
Modify Date: 2024-02-09 16:49:00
3'-O-(t-Butyldimethylsilyl)-2'-deoxy-2'-fluorouridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

Name	2'-Deoxy-3'-O-[dimethyl(2-methyl-2-propanyl)silyl]-2'-fluorouridine
Synonyms	Uridine, 2'-deoxy-3'-O-[(1,1-dimethylethyl)dimethylsilyl]-2'-fluoro- 2'-Deoxy-3'-O-[dimethyl(2-methyl-2-propanyl)silyl]-2'-fluorouridine

Description	3'-O-(t-Butyldimethylsilyl)-2'-deoxy-2'-fluorouridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog
References	[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.