900701-83-9

900701-83-9 structure

Name: 1-(2-Chlorobenzyl)-3-(4-nitrophenyl)thiourea
Chemical Name: 1-(2-Chlorobenzyl)-3-(4-nitrophenyl)thiourea
CAS Number: 900701-83-9
Molecular Formula: C₁₄H₁₂ClN₃O₂S
Molecular Weight: 321.782
Catalog: Signaling Pathways Anti-infection Bacterial
Create Date: 2018-07-02 08:05:16
Modify Date: 2024-01-10 09:03:42
InhA-IN-3 (Compound TU12) is a Mycobacterium tuberculosis InhA (an enoyl ACP-reductase) inhibitor with an IC50 of 17.7 μM[1].

Name	1-(2-Chlorobenzyl)-3-(4-nitrophenyl)thiourea
Synonyms	1-(2-Chlorobenzyl)-3-(4-nitrophenyl)thiourea Thiourea, N-[(2-chlorophenyl)methyl]-N'-(4-nitrophenyl)- MFCD04154139

Description	InhA-IN-3 (Compound TU12) is a Mycobacterium tuberculosis InhA (an enoyl ACP-reductase) inhibitor with an IC50 of 17.7 μM[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Bacterial
Target	IC50: 17.7 μM (InhA)[1]
In Vitro	InhA-IN-3 (Compound TU12) shows antitubercular activity with a MIC of 0.78±0.59 µg/mL against Mycobacterium tuberculosis[1].
References	[1]. Doğan ŞD, et al. Design and synthesis of thiourea-based derivatives as Mycobacterium tuberculosis growth and enoyl acyl carrier protein reductase (InhA) inhibitors. Eur J Med Chem. 2020 Aug 1;199:112402.