10212-16-5

10212-16-5 structure

Name: 2'-Deoxy-2'-fluoro-4-thiouridine
Chemical Name: 1-(2-Deoxy-2-fluoro-β-D-ribofuranosyl)-4-thioxo-3,4-dihydro-2(1H)-pyrimidinone
CAS Number: 10212-16-5
Molecular Formula: C₉H₁₁FN₂O₄S
Molecular Weight: 262.26
Catalog: Signaling Pathways Cell Cycle/DNA Damage Nucleoside Antimetabolite/Analog
Create Date: 2018-06-21 03:32:24
Modify Date: 2024-01-15 14:18:56
2'-Deoxy-2'-fluoro-4-thiouridine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

Name	1-(2-Deoxy-2-fluoro-β-D-ribofuranosyl)-4-thioxo-3,4-dihydro-2(1H)-pyrimidinone
Synonyms	2(1H)-Pyrimidinone, 1-(2-deoxy-2-fluoro-β-D-ribofuranosyl)-3,4-dihydro-4-thioxo- 1-(2-deoxy-2-fluoro-β-D-ribofuranosyl)-4-thioxo-3,4-dihydropyrimidin-2(1H)-one 1-(2-Deoxy-2-fluoro-β-D-ribofuranosyl)-4-thioxo-3,4-dihydro-2(1H)-pyrimidinone

Description	2'-Deoxy-2'-fluoro-4-thiouridine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].
Related Catalog	Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog Research Areas >> Others
References	[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.