149234-04-8

149234-04-8 structure

Name: Thrombospondin-1 (1016-1023) (human, bovine, mouse)
Chemical Name: N5-(Diaminomethylene)-L-ornithyl-L-phenylalanyl-L-tyrosyl-L-valyl-L-valyl-L-methionyl-L-tryptophyl-L-lysine
CAS Number: 149234-04-8
Molecular Formula: C₅₆H₈₁N₁₃O₁₀S
Molecular Weight: 1128.388
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2018-06-05 22:29:31
Modify Date: 2024-01-21 11:52:23
Thrombospondin-1 (1016-1023) (human, bovine, mouse), is the C-terminal end of the native sequence of Thrombospondin-1 (TSP-1), is a CD47 agonist peptide[1].

Name	N5-(Diaminomethylene)-L-ornithyl-L-phenylalanyl-L-tyrosyl-L-valyl-L-valyl-L-methionyl-L-tryptophyl-L-lysine
Synonyms	L-Lysine, N5-(diaminomethylene)-L-ornithyl-L-phenylalanyl-L-tyrosyl-L-valyl-L-valyl-L-methionyl-L-tryptophyl- N5-(Diaminomethylene)-L-ornithyl-L-phenylalanyl-L-tyrosyl-L-valyl-L-valyl-L-methionyl-L-tryptophyl-L-lysine

Description	Thrombospondin-1 (1016-1023) (human, bovine, mouse), is the C-terminal end of the native sequence of Thrombospondin-1 (TSP-1), is a CD47 agonist peptide[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Inflammation/Immunology
In Vitro	Thrombospondin-1 (1016-1023) (human, bovine, mouse) (4N1K; 100 µg/mL; for 60 min) 处理会导致单核细胞来源的未成熟树突状细胞 (DC) 中的磷脂酰丝氨酸暴露和细胞膜完整性丧失。当肽浓度为 25-200 µg/mL 时，膜联蛋白 V+ 细胞的数量会随着肽浓度的增加而增加。Thrombospondin-1 (1016-1023) (human, bovine, mouse) 可降低 DC 中的线粒体膜电位和片段化 DNA[2]。
References	[1]. Chih-Jian Lih, et al. Txr1: a transcriptional regulator of thrombospondin-1 that modulates cellular sensitivity to taxanes. Genes Dev. 2006 Aug 1;20(15):2082-95. [2]. U Johansson, et al. CD47 ligation induces a rapid caspase-independent apoptosis-like cell death in human monocytes and dendritic cells. Scand J Immunol. 2004 Jan;59(1):40-9.