443776-49-6

443776-49-6 structure

Name: BC11 hydrobromide
Chemical Name: {4-[(Carbamimidoylsulfanyl)methyl]phenyl}boronic acid hydrobromide (1:1)
CAS Number: 443776-49-6
Molecular Formula: C₈H₁₂BBrN₂O₂S
Molecular Weight: 290.97
Catalog: Signaling Pathways Anti-infection SARS-CoV
Create Date: 2018-06-16 01:36:27
Modify Date: 2024-04-08 14:40:55
BC-11 hydrobromide is a selective TMPRSS2 inhibitor (TMPRSS2 is a key host cellular factor for viral entry and SARS-CoV-2 pathogenesis), and a selective urokinase (uPA) inhibitor (IC50=8.2 μM). BC-11 hydrobromide is cytotoxic to triple-negative MDA-MB231 breast cancer cells. BC-11 hydrobromide is used in research on viral infections and cancer[1][2][3].

Name	{4-[(Carbamimidoylsulfanyl)methyl]phenyl}boronic acid hydrobromide (1:1)
Synonyms	{4-[(Carbamimidoylsulfanyl)methyl]phenyl}boronic acid hydrobromide (1:1) Carbamimidothioic acid, (4-boronophenyl)methyl ester, hydrobromide (1:1)

Description	BC-11 hydrobromide is a selective TMPRSS2 inhibitor (TMPRSS2 is a key host cellular factor for viral entry and SARS-CoV-2 pathogenesis), and a selective urokinase (uPA) inhibitor (IC50=8.2 μM). BC-11 hydrobromide is cytotoxic to triple-negative MDA-MB231 breast cancer cells. BC-11 hydrobromide is used in research on viral infections and cancer[1][2][3].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> PAI-1 Signaling Pathways >> Metabolic Enzyme/Protease >> Ser/Thr Protease Research Areas >> Cancer Research Areas >> Infection Signaling Pathways >> Anti-infection >> SARS-CoV
Target	IC50: 8.2 μM (uPA)[3].
References	[1]. Moumbock AFA, et al. BC-11 is a covalent TMPRSS2 fragment inhibitor that impedes SARS-CoV-2 host cell entry. Arch Pharm (Weinheim). 2023 Jan;356(1):e2200371. [2]. Semina E, et al. Urokinase and urokinase receptor participate in regulation of neuronal migration, axon growth and branching. Eur J Cell Biol. 2016 Sep;95(9):295-310. [3]. Longo A, et al. Cytotoxicity of the Urokinase-Plasminogen Activator Inhibitor Carbamimidothioic Acid (4-Boronophenyl) Methyl Ester Hydrobromide (BC-11) on Triple-Negative MDA-MB231 Breast Cancer Cells. Molecules. 2015 May 28;20(6):9879-89.