11023-94-2
11023-94-2 structure
- Name: Nothofagin
- Chemical Name: Nothofagin
- CAS Number: 11023-94-2
- Molecular Formula: C21H24O10
- Molecular Weight: 436.409
- Catalog: Signaling Pathways Membrane Transporter/Ion Channel Calcium Channel
- Create Date: 2018-06-13 11:45:53
- Modify Date: 2024-01-09 08:50:39
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Nothofagin, a dihydrochalcone, is isolated from rooibos (Aspalathus linearis)[1]. Nothofagin downregulates NF-κB translocation through blocking calcium influx. Nothofagin has antioxidant activity and ameliorates various inflammatory responses such as the septic response and vascular inflammation[2].
| Name | Nothofagin |
|---|---|
| Synonyms |
Nothofagin
(1S)-1,5-Anhydro-1-{2,4,6-trihydroxy-3-[3-(4-hydroxyphenyl)propanoyl]phenyl}-D-glucitol D-Glucitol, 1,5-anhydro-1-C-[2,4,6-trihydroxy-3-[3-(4-hydroxyphenyl)-1-oxopropyl]phenyl]-, (1S)- 1-(3-beta-D-Glucopyranosyl-2,4,6-trihydroxyphenyl)-3-(4-hydroxyphenyl)-1-propanone |
| Description | Nothofagin, a dihydrochalcone, is isolated from rooibos (Aspalathus linearis)[1]. Nothofagin downregulates NF-κB translocation through blocking calcium influx. Nothofagin has antioxidant activity and ameliorates various inflammatory responses such as the septic response and vascular inflammation[2]. |
|---|---|
| Related Catalog | |
| In Vitro | Nothofagin pre-treatment (0.1, 1, 10 μM) decreases the level of histamine release in RBL-2H3 and RPMCs cells. The production of cytokines are downregulated bynothofagin pre-treatment Nothofagin (TNF-α: 1-10 μM; IL-4: 0.1-10 μM, IL-6: 1-10 μM)[1]. Pre-treatment of DNPHSA-stimulated RBL-2H3 with Nothofagin (10 μM) markedly suppresses the phosphorylation of Lyn, Syk, and Akt[1]. Nothofagin (30 μM; for 6 hours) results in inhibited formation of LPS-induced (100 ng/mL; 4 hours) paracellular gaps with the formation of dense F-actin rings in HUVECs[2]. Nothofagin suppresses IgE-mediated mast cell degranulation both in vitro and in vivo[1]. |
| In Vivo | Nothofagin (1 mg/kg; orally; once a day; for 7 days) significantly increases the urinary volume of both normotensive (NTR) and spontaneously hypertensive rats (SHR)[3]. Animal Model: Male Wistar normotensive and spontaneously hypertensive rats (3-4 months old) [3] Dosage: 1 mg/kg Administration: Orally; once a day; for 7 days Result: Significantly increased the urinary volume of both NTR and SHR. |
| References |
| Density | 1.594±0.06 g/cm3 |
|---|---|
| Boiling Point | 711.5±0.0 °C at 760 mmHg |
| Melting Point | 92-110 ºC (decomp) |
| Molecular Formula | C21H24O10 |
| Molecular Weight | 436.409 |
| Flash Point | 249.4±0.0 °C |
| Exact Mass | 436.136932 |
| LogP | 0.90 |
| Vapour Pressure | 0.0±0.0 mmHg at 25°C |
| Index of Refraction | 1.709 |
| Water Solubility | Very slightly soluble (0.92 g/L) (25 ºC) |