112748-19-3

112748-19-3 structure

Name: Scyliorhinin II
Chemical Name: 2,2'-[(6R,11R,12E,14S,15E,16aS,23E,25S,26E,27aS)-6-({(2S,5S,8S,11S)-2-(4-Aminobutyl)-1,4,7,10,13-pentahydroxy-8-(2-hydroxy-2-iminoethyl)-5,11-bis(hydroxymethyl)-13-[(2S)-1-(L-seryl)-2-pyrrolidinyl]-3,6,9,12-tetraazatrideca-3,6,9,12-tetraen-1-ylidene}amino)-11-{(3S,6S,12S,15S)-3-benzyl-1,4,7,10,13-pentahydroxy-15-[hydroxy(imino)methyl]-12-isobutyl-6-isopropyl-18-thia-2,5,8,11,14-pentaazanonadeca-1,4,7,10,13-pentaen-1-yl}-13,16,24,27-tetrahydroxy-5,21-dioxo-2,3,6,7,11,14,16a,17,18,19,21,22,25,27a-tetradecahydro-1H,5H,10H-dipyrrolo[2,1-j:2',1'-s][1,2,5,8,11,14,17,20]dithiahexaazacyclotricosine-14,25-diyl]diacetic acid
CAS Number: 112748-19-3
Molecular Formula: C₇₇H₁₁₉N₂₁O₂₆S₃
Molecular Weight: 1851.089
Catalog: Peptides
Create Date: 2018-07-20 20:27:34
Modify Date: 2024-01-09 18:55:16
Scyliorhinin II is a selective neurokinin-3 receptor agonist, with a Ki of 2.5 nM for neurokinin-3 receptor in rat cerebral cortex.

Name	2,2'-[(6R,11R,12E,14S,15E,16aS,23E,25S,26E,27aS)-6-({(2S,5S,8S,11S)-2-(4-Aminobutyl)-1,4,7,10,13-pentahydroxy-8-(2-hydroxy-2-iminoethyl)-5,11-bis(hydroxymethyl)-13-[(2S)-1-(L-seryl)-2-pyrrolidinyl]-3,6,9,12-tetraazatrideca-3,6,9,12-tetraen-1-ylidene}amino)-11-{(3S,6S,12S,15S)-3-benzyl-1,4,7,10,13-pentahydroxy-15-[hydroxy(imino)methyl]-12-isobutyl-6-isopropyl-18-thia-2,5,8,11,14-pentaazanonadeca-1,4,7,10,13-pentaen-1-yl}-13,16,24,27-tetrahydroxy-5,21-dioxo-2,3,6,7,11,14,16a,17,18,19,21,22,25,27a-tetradecahydro-1H,5H,10H-dipyrrolo[2,1-j:2',1'-s][1,2,5,8,11,14,17,20]dithiahexaazacyclotricosine-14,25-diyl]diacetic acid
Synonyms	Scyliorhinin II

Description	Scyliorhinin II is a selective neurokinin-3 receptor agonist, with a Ki of 2.5 nM for neurokinin-3 receptor in rat cerebral cortex.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Neurokinin Receptor Signaling Pathways >> Neuronal Signaling >> Neurokinin Receptor Research Areas >> Neurological Disease Peptides
Target	Ki: 2.5 nM (Neurokinin-3 receptor)[1]
In Vitro	Scyliorhinin II is a neurokinin-3 selective tachykinin receptor, with a Ki of 2.5 nM for neurokinin-3 (NK-3) receptor in rat cerebral cortex. Scyliorhinin II has little effect on NK-1 and NK-2 receptors, with Ki (NK-1 receptor)/Ki (NK-3 receptor) and Ki (NK-2 receptor)/Ki (NK-3 receptor) of 176 and 200[1].
In Vivo	Scyliorhinin II produces potent, dose-related reciprocal hindlimb scratching about equipotently with an ED50 of 0.08 nmol via intracerebroventricularly (i.c.v.) administration in mice[2].
References	[1]. Buck SH, et al. The dogfish peptides scyliorhinin I and scyliorhinin II bind with differential selectivity to mammalian tachykinin receptors. Eur J Pharmacol. 1987 Nov 24;144(1):109-11. [2]. Raffa RB, et al. Scyliorhinin-I and -II induce reciprocal hindlimb scratching in mice: differentiation of spinal and supraspinal neurokinin receptors in vivo. Neurosci Lett. 1993 Aug 6;158(1):87-91.