122018-91-1

122018-91-1 structure

Name: prepro-thyrotropin releasing hormone (160-169)
Chemical Name: L-Seryl-L-phenylalanyl-L-prolyl-L-tryptophyl-L-methionyl-L-α-glutamyl-L-seryl-L-α-aspartyl-L-valyl-L-threonine
CAS Number: 122018-91-1
Molecular Formula: C₅₄H₇₅N₁₁O₁₈S
Molecular Weight: 1198.301
Catalog: Research Areas Endocrinology
Create Date: 2018-06-16 02:15:23
Modify Date: 2024-01-07 18:42:39
Prepro-TRH-(160-169) is one of the connecting peptides of thyrotropin-releasing hormone prohormone (pro-TRH), potentiates TRH-induced thyrotropin (TSH) release[1].

Name	L-Seryl-L-phenylalanyl-L-prolyl-L-tryptophyl-L-methionyl-L-α-glutamyl-L-seryl-L-α-aspartyl-L-valyl-L-threonine
Synonyms	L-Threonine, L-seryl-L-phenylalanyl-L-prolyl-L-tryptophyl-L-methionyl-L-α-glutamyl-L-seryl-L-α-aspartyl-L-valyl- L-Seryl-L-phenylalanyl-L-prolyl-L-tryptophyl-L-methionyl-L-α-glutamyl-L-seryl-L-α-aspartyl-L-valyl-L-threonine

Description	Prepro-TRH-(160-169) is one of the connecting peptides of thyrotropin-releasing hormone prohormone (pro-TRH), potentiates TRH-induced thyrotropin (TSH) release[1].
Related Catalog	Research Areas >> Endocrinology Signaling Pathways >> Others >> Thyroid Hormone Receptor Research Areas >> Neurological Disease
In Vitro	在大鼠垂体前叶细胞的原代培养物中，Prepro-TRH-(160-169) (Ps4) 能够在 15 秒内迅速增加细胞内 Ca2+ 浓度（[Ca2+] i) [2]。
In Vivo	在氨基甲酸乙酯麻醉的大鼠中，Prepro-TRH-(160-169)（Ps4；100 ng、150 ng 和 200 ng；注入背运动核 (DMN)）通过肽和位点特异性的作用增强 DMN 诱发的胃酸分泌中的 TRH：是肽和位点特异性的[1]。
References	[1]. H Yang, et al. Prepro-TRH-(160-169) potentiates gastric acid secretion stimulated by TRH microinjected into the dorsal motor nucleus of the vagus. Neurosci Lett. 1994 Jun 6;174(1):43-6. [2]. J P Roussel, et al. Somatostatin blocks the potentiation of TRH-induced TSH secretion from perifused pituitary fragments and the change in intracellular calcium concentrations from dispersed pituitary cells elicited by prepro-TRH (PS4) or by tri-iodothyronine. J Mol Endocrinol. 1997 Aug;19(1):87-97.