1000403-03-1

1000403-03-1 structure

Name: INT-767
Chemical Name: INT-767
CAS Number: 1000403-03-1
Molecular Formula: C₂₅H₄₃NaO₆S
Molecular Weight: 494.66
Catalog: Signaling Pathways GPCR/G Protein GPCR19
Create Date: 2018-07-11 20:54:18
Modify Date: 2024-01-11 01:10:41
INT-767 is a dual farnesoid X receptor/TGR5 agonist with mean EC50s of 30 and 630 nM, respectively.

Name	INT-767

Description	INT-767 is a dual farnesoid X receptor/TGR5 agonist with mean EC50s of 30 and 630 nM, respectively.
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> FXR Signaling Pathways >> GPCR/G Protein >> GPCR19 Research Areas >> Cancer
References	[1]. Baghdasaryan A, et al. Dual farnesoid X receptor/TGR5 agonist INT-767 reduces liver injury in the Mdr2-/- (Abcb4-/-) mousecholangiopathy model by promoting biliary HCO3- output. Hepatology. 2011 Oct;54(4):1303-1312. [2]. Rizzo G, et al. Functional characterization of the semisynthetic bile acid derivative INT-767, a dual farnesoid X receptor andTGR5 agonist. Mol Pharmacol. 2010 Oct;78(4):617-630.