1228100-59-1

1228100-59-1 structure

Name: TAMRA-PEG3-Azide
Chemical Name: TAMRA-PEG3-Azide
CAS Number: 1228100-59-1
Molecular Formula: C₃₃H₃₈N₆O₇
Molecular Weight: 646.733
Catalog: Signaling Pathways PROTAC PROTAC Linker
Create Date: 2018-06-27 11:41:18
Modify Date: 2024-01-11 20:24:39
TAMRA-PEG3-Azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name	TAMRA-PEG3-Azide
Synonyms	2-[6-(Dimethylamino)-3-(dimethyliminio)-3H-xanthen-9-yl]benzoate - N-(2-{2-[2-(2-azidoethoxy)ethoxy]ethoxy}ethyl)acetamide (1:1) MFCD28334528

Description	TAMRA-PEG3-Azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562