1234627-85-0

1234627-85-0 structure

Name: BAF-312 fumarate
Chemical Name: Siponimod
CAS Number: 1234627-85-0
Molecular Formula: C₆₂H₇₄F₆N₄O₁₀
Molecular Weight: 1149.262
Catalog: Signaling Pathways GPCR/G Protein LPL Receptor
Create Date: 2018-06-19 05:15:55
Modify Date: 2024-01-09 17:49:49
Siponimod (BAF-312) hemifumarate is a potent and selective sphingosine-1-phosphate (S1P) receptor modulator. Siponimod hemifumarate is selective for S1P1 and S1P5 receptors over S1P2, S1P3, and S1P4 (EC50s of 0.39, 0.98, >10000, >1000, and 750 nM, respectively). Siponimod hemifumarate can be used for multiple sclerosis (MS) research[1][2].

Name	Siponimod
Synonyms	3-Azetidinecarboxylic acid, 1-[[4-[(1E)-1-[[[4-cyclohexyl-3-(trifluoromethyl)phenyl]methoxy]imino]ethyl]-2-ethylphenyl]methyl]-, (2E)-2-butenedioate (2:1) 1-{4-[(1E)-N-{[4-Cyclohexyl-3-(trifluoromethyl)benzyl]oxy}ethanimidoyl]-2-ethylbenzyl}-3-azetidinecarboxylic acid (2E)-2-butenedioate (2:1) MFCD31536984 Siponimod Fumarate

Description	Siponimod (BAF-312) hemifumarate is a potent and selective sphingosine-1-phosphate (S1P) receptor modulator. Siponimod hemifumarate is selective for S1P1 and S1P5 receptors over S1P2, S1P3, and S1P4 (EC50s of 0.39, 0.98, >10000, >1000, and 750 nM, respectively). Siponimod hemifumarate can be used for multiple sclerosis (MS) research[1][2].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> LPL Receptor Research Areas >> Inflammation/Immunology Research Areas >> Neurological Disease
Target	S1PR1:0.39 nM (EC50) S1PR5:0.98 nM (EC50) S1PR4:750 nM (EC50) S1PR3:>1000 nM (EC50) S1PR2:>10000 nM (EC50)
References	[1]. Pan S, et al. Discovery of BAF312 (Siponimod), a Potent and Selective S1P Receptor Modulator. ACS Med Chem Lett. 2013 Jan 4;4(3):333-7. [2]. McGinley M, et al. Prospects of siponimod in secondary progressive multiple sclerosis. Ther Adv Neurol Disord. 2018 Jul 17;11:1756286418788013. [3]. Behrangi N, et al. Mechanism of Siponimod: Anti-Inflammatory and Neuroprotective Mode of Action. Cells. 2019 Jan 7;8(1):24.