1345681-71-1

1345681-71-1 structure

Name: Amino-PEG12-alcohol
Chemical Name: H2N-PEG12-OH
CAS Number: 1345681-71-1
Molecular Formula: C₂₄H₅₁NO₁₂
Molecular Weight: 545.661
Catalog: Signaling Pathways PROTAC PROTAC Linker
Create Date: 2018-07-01 04:05:36
Modify Date: 2024-01-02 11:46:53
Amino-PEG12-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name	H2N-PEG12-OH
Synonyms	35-Amino-3,6,9,12,15,18,21,24,27,30,33-undecaoxapentatriacontan-1-ol 3,6,9,12,15,18,21,24,27,30,33-Undecaoxapentatriacontan-1-ol, 35-amino- Amino-dPEG(R)12-OH MFCD11041097

Description	Amino-PEG12-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562