Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 1-((4'-(cyclopropylmethyl)-2-(pyridin-4-ylamino)-[4,5'-bipyrimidin]-2'-yl)amino)-2-methylpropan-2-ol
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1383716-46-8

1383716-46-8 structure

Name: VPS34 inhibitor 1 (Compound 19, PIK-III analogue)
Chemical Name: Vps
CAS Number: 1383716-46-8
Molecular Formula: C₂₁H₂₅N₇O
Molecular Weight: 391.47
Catalog: Signaling Pathways Autophagy Autophagy
Create Date: 2018-06-13 07:09:12
Modify Date: 2024-01-14 10:01:11
Vps34-IN-4 (compound 19) is a potent, selective, and orally active inhibitor of VPS34. Vps34-IN-4 inhibits the autophagy in vivo. Autophagy is a dynamic process that regulates lysosomal-dependent degradation of cellular components[1].

Name	Vps
Synonyms	VPS34

Description	Vps34-IN-4 (compound 19) is a potent, selective, and orally active inhibitor of VPS34. Vps34-IN-4 inhibits the autophagy in vivo. Autophagy is a dynamic process that regulates lysosomal-dependent degradation of cellular components[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PI3K/Akt/mTOR >> PI3K Signaling Pathways >> Autophagy >> Autophagy
References	[1]. Honda A, et al. Potent, Selective, and Orally Bioavailable Inhibitors of VPS34 Provide Chemical Tools to Modulate Autophagy in Vivo. ACS Med Chem Lett. 2015;7(1):72-76.