1918143-53-9
1918143-53-9 structure
- Name: Galicaftor
- Chemical Name: ABBV-2222 (GLPG2222)
- CAS Number: 1918143-53-9
- Molecular Formula: C28H21F4NO7
- Molecular Weight: 559.46
- Catalog: Signaling Pathways Membrane Transporter/Ion Channel CFTR
- Create Date: 2018-06-26 22:28:24
- Modify Date: 2024-01-28 17:32:08
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Galicaftor (ABBV-2222; GLPG-2222) is a potent and orally active cystic fibrosis transmembrane conductance regulator (CFTR) corrector. Galicaftor can be used for cystic fibrosis research[1].
| Name | ABBV-2222 (GLPG2222) |
|---|---|
| Synonyms |
Benzoic acid, 4-[(2R,4R)-4-[[[1-(2,2-difluoro-1,3-benzodioxol-5-yl)cyclopropyl]carbonyl]amino]-7-(difluoromethoxy)-3,4-dihydro-2H-1-benzopyran-2-yl]-
4-[(2R,4R)-4-({[1-(2,2-Difluoro-1,3-benzodioxol-5-yl)cyclopropyl]carbonyl}amino)-7-(difluoromethoxy)-3,4-dihydro-2H-chromen-2-yl]benzoic acid galicaftor |
| Description | Galicaftor (ABBV-2222; GLPG-2222) is a potent and orally active cystic fibrosis transmembrane conductance regulator (CFTR) corrector. Galicaftor can be used for cystic fibrosis research[1]. |
|---|---|
| Related Catalog | |
| In Vitro | Galicaftor (ABBV-2222; GLPG-2222) exhibits potent in vitro functional activity in primary patient cells harboring F508del/F508del CFTR, with an EC50 <10 nM[2]. |
| In Vivo | The rat pharmacokinetic tests are performed on Galicaftor (ABBV-2222; GLPG-2222; 1 mg/kg, i.v.; 1 mg/kg, p.o.) to illustrate its pharmacokinetic properties in rats. The T1/2 is 2.7 hours (i.v.). And for intragastric administration, the bioavailability (%F) is 74%[1]. |
| References |
| Density | 1.6±0.1 g/cm3 |
|---|---|
| Boiling Point | 701.1±60.0 °C at 760 mmHg |
| Molecular Formula | C28H21F4NO7 |
| Molecular Weight | 559.46 |
| Flash Point | 377.8±32.9 °C |
| Exact Mass | 559.125427 |
| LogP | 6.05 |
| Vapour Pressure | 0.0±2.3 mmHg at 25°C |
| Index of Refraction | 1.640 |