119189-70-7

119189-70-7 structure

Name: Bis-PEG6-acid
Chemical Name: Bis-PEG6-acid
CAS Number: 119189-70-7
Molecular Formula: C₁₆H₃₀O₁₀
Molecular Weight: 382.403
Catalog: Signaling Pathways PROTAC PROTAC Linker
Create Date: 2018-11-30 09:32:09
Modify Date: 2024-01-04 23:36:48
Bis-PEG6-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].

Name	Bis-PEG6-acid
Synonyms	4,7,10,13,16,19-Hexaoxadocosane-1,22-dioic acid MFCD20926399

Description	Bis-PEG6-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
References	[1]. Zorba A, et al. Delineating the role of cooperativity in the design of potent PROTACs for BTK. Proc Natl Acad Sci U S A. 2018 Jul 31;115(31):E7285-E7292.