143863-88-1

143863-88-1 structure

Name: Neuropeptide Y (3-36) (porcine) trifluoroacetate salt
Chemical Name: NEUROPEPTIDE Y (3-36) (PORCINE)
CAS Number: 143863-88-1
Molecular Formula: C₁₇₆H₂₇₁N₅₃O₅₄
Molecular Weight: 3993.36
Catalog: Signaling Pathways GPCR/G Protein Neuropeptide Y Receptor
Create Date: 2018-06-03 06:33:13
Modify Date: 2024-01-08 18:55:29
Neuropeptide Y (3-36) (porcine) is an agonist of neuropeptide Y (NPY) receptor subtype Y2, and stimulates feeding in rats. Neuropeptide Y (3-36) (porcine) is a highly Y2 selective ligand compared with nselective Y1/Y2 receptor ligand, Neuropeptide Y 1-36[1][2][3].

Name	NEUROPEPTIDE Y (3-36) (PORCINE)
Synonyms	SER-LYS-PRO-ASP-ASN-PRO-GLY-GLU-ASP-ALA-PRO-ALA-GLU-ASP-LEU-ALA-ARG-TYR-TYR-SER-ALA-LEU-ARG-HIS-TYR-ILE-ASN-LEU-ILE-THR-ARG-GLN-ARG-TYR-NH2

Description	Neuropeptide Y (3-36) (porcine) is an agonist of neuropeptide Y (NPY) receptor subtype Y2, and stimulates feeding in rats. Neuropeptide Y (3-36) (porcine) is a highly Y2 selective ligand compared with nselective Y1/Y2 receptor ligand, Neuropeptide Y 1-36[1][2][3].
Related Catalog	Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> Neuropeptide Y Receptor
Target	NPY Y2 receptor
In Vitro	Neuropeptide Y (3-36) (porcine) accounts for 35% of NPY-like immunoreactivity in porcine brain[2]. Neuropeptide Y (3-36) (porcine) shows high affinity for Y2-like receptors on CHP234 cells, and light affinity Y1-like receptors on SK-N-MC cells[2].
In Vivo	Neuropeptide Y (3-36) (porcine) (0.24-24 nM; i.c.v.; single dose) induces feeding in the rat in a dose-dependent manner[1]. Neuropeptide Y (3-36) (porcine) (4 μg, 8 μg; i.c.v.; single dose) significantly increased food intake at 2 and 3 h, results dose-dependently orexigenic effect in rainbow trout (Oncorhynchus mykiss)[2]. Animal Model: Adult male Wistar rats (250-300 g)[1] Dosage: 0.24, 0.72, 2.4, 7.2, 24 nM per animal Administration: Intracerebroventricular injection; single dose Result: Stimulated rat feeding dose-dependently. Produced no feeding effect alone, that Y2 activation alone elicited no feeding response.

WGK Germany	3