150433-82-2

150433-82-2 structure

Name: w-Conotoxin SVIB
Chemical Name: OMEGA-CONOTOXIN SVIB
CAS Number: 150433-82-2
Molecular Formula: C₁₀₅H₁₇₆N₃₈O₃₆S₆
Molecular Weight:
Catalog: Research Areas Neurological Disease
Create Date: 2018-06-16 04:26:10
Modify Date: 2024-01-08 18:01:45
w-Conotoxin SVIB is a peptide toxin, it can be isolated from Conus venoms. w-Conotoxin SVIB inhibits twitch response with an IC50 value of 37 nM. w-Conotoxin SVIB induces respiratory distress and it can be lethal to mice at a high concentration[1][2].

Name	OMEGA-CONOTOXIN SVIB

Description	w-Conotoxin SVIB is a peptide toxin, it can be isolated from Conus venoms. w-Conotoxin SVIB inhibits twitch response with an IC50 value of 37 nM. w-Conotoxin SVIB induces respiratory distress and it can be lethal to mice at a high concentration[1][2].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease
Target	IC50: 37 nM (twitch response at 0.1 Hz)[2]
In Vitro	w-Conotoxin SVIB (0.1-1000 nM; 20 min) inhibits twitch response at 0.1 Hz with an IC50 value of 37 nM[2].
In Vivo	w-Conotoxin SVIB (20 pmol/g; s.c. once) causes paralysis and death in fish[1]. w-Conotoxin SVIB causes mouse respiratory distress at around 70 pmol/g and it is lethal to mouse at around 300 pmol/g[1].
References	[1]. Ramilo CA, et al. Novel alpha- and omega-conotoxins from Conus striatus venom. Biochemistry. 1992 Oct 20;31(41):9919-26. [2]. Hong SJ, et al. Inhibition of neuromuscular transmission in the myenteric plexus of guinea-pig ileum by omega-conotoxins GVIA, MVIIA, MVIIC and SVIB. Br J Pharmacol. 1996 Jun;118(3):797-803.

Molecular Formula	C₁₀₅H₁₇₆N₃₈O₃₆S₆
Storage condition	−20°C

WGK Germany	3