629167-92-6
629167-92-6 structure
- Name: Mipomersen sodium
- Chemical Name: MipoMersen sodiuM
- CAS Number: 629167-92-6
- Molecular Formula: C230H305N67Na19O122P19S19
- Molecular Weight:
- Catalog: Research Areas Metabolic Disease
- Create Date: 2019-01-15 06:52:57
- Modify Date: 2024-01-09 11:13:37
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Mipomersen (sodium) is a second-generation 20-base phosphorothioate ASO targeted to human apoB-100[1][2].
| Name | MipoMersen sodiuM |
|---|---|
| Synonyms |
Kynamro
mipomersen |
| Description | Mipomersen (sodium) is a second-generation 20-base phosphorothioate ASO targeted to human apoB-100[1][2]. |
|---|---|
| Related Catalog | |
| In Vitro | Mipomersen predominantly distributes to the liver and decreases the production of apoB-100, the primary structural protein of the atherogenic lipoproteins including low density lipoprotein (LDL), thereby reducing plasma LDL-cholesterol and apoB-100 concentrations[2]. Apolipoprotein (apo) B, a large amphipathic protein, plays a fundamental role in human lipoprotein metabolism. ApoB-100 is also a ligand for LDL receptor-mediated endocytosis of LDL by cells[2]. |
| References |
[1]. Philip Hair, et al. Mipomersen sodium: first global approval. Drugs. 2013 Apr;73(5):487-93. |
| Molecular Formula | C230H305N67Na19O122P19S19 |
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