Shanghai Nianxing Industrial Co., Ltd
China
Product Name: β-Amyloid (10-35), amide
Price:
Purity: 98.0%
Stocking Period: 10 Day
Contact: Yang

Taiwan Oyi peptide Co. Ltd
China
Product Name: β-Amyloid (10-35), amide
Price: $Inquiry/1mg $Inquiry/100kg
Purity: 98.0%
Stocking Period: 1 Day
Contact: Vinnie

181427-66-7

181427-66-7 structure

181427-66-7 structure

Name: β-Amyloid (10-35), amide
Chemical Name: β-Amyloid (10-35), amide
CAS Number: 181427-66-7
Molecular Formula: C₁₃₃H₂₀₅N₃₅O₃₆S
Molecular Weight: 2902.33
Catalog: Peptides
Create Date: 2018-08-20 04:17:04
Modify Date: 2024-01-08 18:10:39
β-Amyloid (10-35), amide is composed of 26 aa (10-35 residues of the Aβ peptide) and is the primary component of the amyloid plaques of Alzheimer’s disease.

Name	β-Amyloid (10-35), amide

Description	β-Amyloid (10-35), amide is composed of 26 aa (10-35 residues of the Aβ peptide) and is the primary component of the amyloid plaques of Alzheimer’s disease.
Related Catalog	Signaling Pathways >> Neuronal Signaling >> Amyloid-β Research Areas >> Neurological Disease Peptides
In Vitro	β-Amyloid (10-35) is selected based on the following considerations: (1) β-Amyloid (10-35) incorporates the core region, point mutations of which significantly obstruct fibril formation and have been used to generate inhibitors of fibrillogenesis; (2) β-Amyloid (10-35) retains the ability to add to bona fide Alzheimer’s plaques, in contrast to other truncated peptides, and forms fibrils morphologically similar to those of the full length peptide; (3) Of most importance, the full length peptide, Aβ(1-42), is intractable for the controlled formation of fibrils from aqueous media because at the earliest time points, some of the peptide exists as an amorphous precipitate. In contrast, the use of β-Amyloid (10-35) allows the reproducible and controlled formation of fibrils from aqueous solutions, under defined conditions of pH, ionic strength, and peptide concentration and thus yields the required homogeneous fibrils[1].
References	[1]. Benzinger TL, et al. Propagating structure of Alzheimer's beta-amyloid(10-35) is parallel beta-sheet with residues in exact register. Proc Natl Acad Sci U S A. 1998 Nov 10;95(23):13407-12.

Molecular Formula	C₁₃₃H₂₀₅N₃₅O₃₆S
Molecular Weight	2902.33