2049868-46-2

2049868-46-2 structure

Name: GSK963
Chemical Name: 1-Propanone, 1-[(5S)-4,5-dihydro-5-phenyl-1H-pyrazol-1-yl]-2,2-dimethyl-
CAS Number: 2049868-46-2
Molecular Formula: C₁₄H₁₈N₂O
Molecular Weight: 230.31
Catalog: Signaling Pathways Apoptosis RIP kinase
Create Date: 2018-08-22 17:23:00
Modify Date: 2024-01-03 15:32:28
GSK963 is a chiral, highly potent and selective inhibitor of RIP1 kinase, with an IC50 of 29 nM. GSK963 is a selective and potent inhibitor of necroptosis in murine and human cells in vitro[1].

Name	1-Propanone, 1-[(5S)-4,5-dihydro-5-phenyl-1H-pyrazol-1-yl]-2,2-dimethyl-
Synonyms	(S)-2,2-dimethyl-1-(5-phenyl-4,5-dihydro-1H-pyrazol-1-yl)propan-1-one

Description	GSK963 is a chiral, highly potent and selective inhibitor of RIP1 kinase, with an IC50 of 29 nM. GSK963 is a selective and potent inhibitor of necroptosis in murine and human cells in vitro[1].
Related Catalog	Signaling Pathways >> Apoptosis >> RIP kinase Research Areas >> Others
Target	IC50: 29 nM (RIP1 in FP binding assay)[1].
References	[1]. Berger SB, et al. Characterization of GSK'963: a structurally distinct, potent and selective inhibitor of RIP1 kinase. Cell Death Discov. 2015 Jul 27;1:15009.