GSK963

Modify Date: 2024-01-03 15:32:28

GSK963 Structure
GSK963 structure
Common Name GSK963
CAS Number 2049868-46-2 Molecular Weight 230.31
Density 1.06±0.1 g/cm3 Boiling Point 342.8±45.0 °C
Molecular Formula C14H18N2O Melting Point N/A
MSDS N/A Flash Point N/A

 Use of GSK963


GSK963 is a chiral, highly potent and selective inhibitor of RIP1 kinase, with an IC50 of 29 nM. GSK963 is a selective and potent inhibitor of necroptosis in murine and human cells in vitro[1].

 Names

Name 1-​Propanone, 1-​[(5S)​-​4,​5-​dihydro-​5-​phenyl-​1H-​pyrazol-​1-​yl]​-​2,​2-​dimethyl-
Synonym More Synonyms

 GSK963 Biological Activity

Description GSK963 is a chiral, highly potent and selective inhibitor of RIP1 kinase, with an IC50 of 29 nM. GSK963 is a selective and potent inhibitor of necroptosis in murine and human cells in vitro[1].
Related Catalog
Target

IC50: 29 nM (RIP1 in FP binding assay)[1].

References

[1]. Berger SB, et al. Characterization of GSK'963: a structurally distinct, potent and selective inhibitor of RIP1 kinase. Cell Death Discov. 2015 Jul 27;1:15009.

 Chemical & Physical Properties

Density 1.06±0.1 g/cm3
Boiling Point 342.8±45.0 °C
Molecular Formula C14H18N2O
Molecular Weight 230.31
Storage condition -20℃

 Synonyms

(S)-2,2-dimethyl-1-(5-phenyl-4,5-dihydro-1H-pyrazol-1-yl)propan-1-one
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