95262-48-9

95262-48-9 structure

Name: Niga-ichigoside F1
Chemical Name: Niga-ichigoside F1
CAS Number: 95262-48-9
Molecular Formula: C₃₆H₅₈O₁₁
Molecular Weight: 666.839
Catalog: Research Areas Cardiovascular Disease
Create Date: 2018-11-18 15:38:40
Modify Date: 2024-01-03 17:06:16
Niga-ichigoside F1, an orally active ursane triterpenoid, has antihyperlipidemic and antioxidant activities. Niga-ichigoside F1 can prevent high-fat diet (HFD)-induced hepatic steatosis[1].

Name	Niga-ichigoside F1
Synonyms	1-O-[(2α,3β)-2,3,19,23-Tetrahydroxy-28-oxours-12-en-28-yl]-β-D-glucopyranose 19α-hydroxyasiatic acid-28-O-β-D-glucopyrannoside β-D-Glucopyranose, 1-O-[(2α,3β)-2,3,19,23-tetrahydroxy-28-oxours-12-en-28-yl]-

Description	Niga-ichigoside F1, an orally active ursane triterpenoid, has antihyperlipidemic and antioxidant activities. Niga-ichigoside F1 can prevent high-fat diet (HFD)-induced hepatic steatosis[1].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Others >> Others
In Vitro	Niga-ichigoside F1 (2.5, 5, 10, 20 μM; for 24 hours) inhibits lipid accumu-lation in free fatty acid (FFA)-treated HepG2 cells in a dose-dependent manner. Niga-ichigoside F1 has no effects on cell viability[1]. Both nuclear and cytoplasmic Nrf2 expressions are lowered in Con, Niga-ichigoside F1 (20 μM), FFA (1 mM), and Niga-ichigoside F1 plus FFA treated Nrf2-silenced cells[1].
In Vivo	Niga-ichigoside F1 (40 mg/kg; oral gavage; for 12 weeks) alleviates hepatic steatosis, possibly by significantly interacting with high-fat diet (HFD) to regulate lipid metabolism genes (including Srebp1c, Acc1, Fasn, Scd1, Cpt1a and Fabp5) in four-week-old male C57BL/6J mice[1].
References	[1]. Shu-Fang Xia, et al. Niga-ichigoside F1 ameliorates high-fat diet-induced hepatic steatosis in male mice by Nrf2 activation. Food Funct. 2018 Feb 21;9(2):906-916.