314054-00-7
314054-00-7 structure
- Name: C 176
- Chemical Name: C-176
- CAS Number: 314054-00-7
- Molecular Formula: C11H7IN2O4
- Molecular Weight: 358.089
- Catalog: Signaling Pathways Immunology/Inflammation STING
- Create Date: 2019-01-20 02:39:01
- Modify Date: 2024-01-20 19:05:37
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C-176 is a strong and covalent mouse STING inhibitor.
| Name | C-176 |
|---|---|
| Synonyms |
2-Furancarboxamide, N-(4-iodophenyl)-5-nitro-
N-(4-Iodophenyl)-5-nitro-2-furamide MFCD00784208 |
| Description | C-176 is a strong and covalent mouse STING inhibitor. |
|---|---|
| Related Catalog | |
| Target |
STING[1]. |
| In Vitro | C-176 strongly reduces STING-mediated, but not RIG-I- or TBK1-mediated, IFNβ reporter activity. Pretreatment with C-176 markedly reduce the CMA-mediated induction of serum levels of type I IFNs and IL-6[1]. |
| In Vivo | Notably, treatment of Trex1−/− mice with C-176 resulted in a significant reduction in serum levels of type I IFNs and in a strong suppression of inflammatory parameters in the heart. Wild-type mice on a two-week treatment with C-176 show no evident signs of overt toxicity. We next conducted a three-month trial with C-176 in Trex1−/− mice, which demonstrated marked amelioration of various signs of systemic inflammation[1]. |
| Animal Admin | Mice[1] C57BL/6J mice are used in the study. For the pharmacokinetic studies, wild-type mice are injected intraperitoneally with 750 nM C-176 per mouse in 200 μL corn oil. To assess the in vivo inhibitory effect of C-176, wild-type mice (8-12 weeks of age) are injected either with vehicle or C-176. To assess the in vivo inhibitory effect of H-151, wild-type mice are injected intraperitoneally with 750 nM H-151 per mouse in 200 μl 10% Tween-80 in PBS. After 1 h CMA (112 mg/kg) is administered, and after 4 h mice are euthanized and the serum is collected. The efficacy study in Trex1−/− mice is conducted as follows: mice (2-5 weeks of age) are injected with 7.5 μL of C-176 or DMSO dissolved in 85 μl corn oil twice per day for 11 consecutive days. Mice are euthanized by anaesthetization in a CO2 chamber followed by cervical dislocation[1]. |
| References |
| Density | 1.9±0.1 g/cm3 |
|---|---|
| Boiling Point | 361.2±37.0 °C at 760 mmHg |
| Molecular Formula | C11H7IN2O4 |
| Molecular Weight | 358.089 |
| Flash Point | 172.3±26.5 °C |
| Exact Mass | 357.945038 |
| LogP | 3.38 |
| Vapour Pressure | 0.0±0.8 mmHg at 25°C |
| Index of Refraction | 1.714 |
| Storage condition | 2-8℃ |