2079886-19-2

2079886-19-2 structure

Name: GSK4028
Chemical Name: GSK4028
CAS Number: 2079886-19-2
Molecular Formula: C₁₇H₂₁BrN₄O
Molecular Weight: 377.28
Catalog: Signaling Pathways Epigenetics Epigenetic Reader Domain
Create Date: 2019-01-20 00:39:05
Modify Date: 2024-01-10 22:15:42
GSK4028 is the enantiomeric negative control of GSK4027, which is a PCAF/GCN5 bromodomain chemical probe, the pIC50 of GSK4028 is 4.9 in a time-resolved fluorescence resonance energy transfer (TR-FRET) assay.

Name	GSK4028

Description	GSK4028 is the enantiomeric negative control of GSK4027, which is a PCAF/GCN5 bromodomain chemical probe, the pIC50 of GSK4028 is 4.9 in a time-resolved fluorescence resonance energy transfer (TR-FRET) assay.
Related Catalog	Signaling Pathways >> Epigenetics >> Epigenetic Reader Domain Signaling Pathways >> Epigenetics >> Histone Acetyltransferase Research Areas >> Inflammation/Immunology Research Areas >> Cancer
Target	pIC50: 4.9 (PCAF/GCN5)[1].
In Vitro	GSK4028 is the enantiomeric negative control of GSK4027, which is a PCAF/GCN5 bromodomain chemical probe, the pIC50 of GSK4028 is 4.9. GSK4028 also demonstrates potency toward BRD4 BD1 and BRD9 inTR-FRET assay with pIC50s of <4.3 and 4.5±0.13, respectively[1].
References	[1]. Humphreys PG, et al. Discovery of a Potent, Cell Penetrant, and Selective p300/CBP-Associated Factor (PCAF)/General Control Nonderepressible 5 (GCN5) Bromodomain Chemical Probe. J Med Chem. 2017 Jan 26;60(2):695-709.