1242441-58-2

1242441-58-2 structure

1242441-58-2 structure

Name: 11C-MK-3168
Chemical Name: 11C-MK-3168
CAS Number: 1242441-58-2
Molecular Formula: C₂₀₁₁CH₂₁ClN₄OS
Molecular Weight: 411.94
Catalog: Signaling Pathways Metabolic Enzyme/Protease FAAH
Create Date: 2019-02-09 12:48:03
Modify Date: 2024-01-09 14:53:52
11C-MK-3168 is a potent, reversible and blood/brain barrier penetrated fatty acid amide hydrolase (FAAH) inhibitor, with IC50s of 1.0, 1.7 and 5.5 nM for human, rat and rhesus FAAH, respectively.

Name	11C-MK-3168

Description	11C-MK-3168 is a potent, reversible and blood/brain barrier penetrated fatty acid amide hydrolase (FAAH) inhibitor, with IC50s of 1.0, 1.7 and 5.5 nM for human, rat and rhesus FAAH, respectively.
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> FAAH Signaling Pathways >> Neuronal Signaling >> FAAH Research Areas >> Others
Target	IC50: 1.0 nM (Human FAAH), 1.7 nM (Rat FAAH), 5.5 nM (Rhesus FAAH)[1]
In Vitro	11C-MK-3168 is a potent and reversible fatty acid amide hydrolase (FAAH) inhibitor, with IC50s of 1.0, 1.7 and 5.5 nM for human, rat and rhesus FAAH, respectively. 11C-MK-3168 also shows selectivity over hERG (IC50 = 37 μM) and DLZ (IC50 = 16 μM); CYP 3A4 (IC50 > 50 μM); and the two cannabinoid receptors, CB1 (IC50 = 30 μM) and CB2 (IC50 = 150 μM)[1].
References	[1]. Liu P, et al. Discovery of MK-3168: A PET Tracer for Imaging Brain Fatty Acid Amide Hydrolase. ACS Med Chem Lett. 2013 Apr 20;4(6):509-13.

Molecular Formula	C₂₀₁₁CH₂₁ClN₄OS
Molecular Weight	411.94